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Arginine metabolism in myeloid cells in health and disease.
Semin Immunopathol
January 2025
Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine and University Hospital Carl Gustav Carus, Technische Universität Dresden, Fetscherstrasse 74, 01307, Dresden, Germany.
Metabolic flexibility is key for the function of myeloid cells. Arginine metabolism is integral to the regulation of myeloid cell responses. Nitric oxide (NO) production from arginine is vital for the antimicrobial and pro-inflammatory responses.
View Article and Find Full Text PDFEstimating Total-Tract Digestibility of Nutrients and Their Contribution to Digestible Energy Supplies in Equine Diets.
J Equine Vet Sci
January 2025
School of Animal Sciences, Virginia Polytechnic Institute and State University, 175 West Campus Dr., Blacksburg, VA, USA, 24061. Electronic address:
Our objectives were to use a quantitative literature review to explore dietary and feed factors influencing apparent total-tract digestibility of dry matter (DMD), crude protein (CPD), neutral detergent fiber (NDFD), ether extract (EED), non-structural carbohydrates (NSCD), non-fiber carbohydrates (NFCD), and residual organic matter (rOMD) in equine diets, and to assess their contributions to digestible energy (DE) supplies. Data from 54 studies were modeled using linear mixed-effect regressions, with publication as a random effect to account for study variability. For each nutrient, five models were derived with explanatory variables including: dry matter intake (DMI; % BW/day) and DM (% as-fed), and dietary components (CP, organic matter, EE, NDF, acid detergent fiber, NSC, starch, and NFC as % of DM), and feed types (forage, non-forage fiber, legumes, cereal, and oil proportions).
View Article and Find Full Text PDFOXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth.
Mol Cell
January 2025
Zhejiang Provincial Key Laboratory of Pancreatic Disease, the First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China; Institute of Fundamental and Transdisciplinary Research, Cancer Center, Zhejiang University, Hangzhou, Zhejiang 310029, China. Electronic address:
Ketone bodies generated in hepatocytes in the adult liver are used for nonhepatic tissues as an energy source. However, ketolysis is reactivated in hepatocellular carcinoma (HCC) cells with largely unelucidated mechanisms. Here, we demonstrate that 3-oxoacid CoA-transferase 1 (OXCT1), a rate-limiting enzyme in ketolysis, interacts with SUCLA2 upon IGF1 stimulation in HCC cells.
View Article and Find Full Text PDFMixotrophic denitrification using thiocyanate as an electron donor: Role of thiocyanate under different C/N conditions.
J Environ Manage
January 2025
School of Biology and Biological Engineering, South China University of Technology, Guangzhou, 510006, PR China. Electronic address:
Thiocyanate (SCN) is a highly toxic reducing inorganic compound commonly found in various nitrogen-rich wastewater and is also a promising electron donor for mixotrophic denitrification. However, its extent of involvement in mixotrophic denitrification under conditions of carbon limitation or excess remains unclear. In this study, five reactors were constructed to investigate the participation and microbial mechanisms of SCN in mixotrophic denitrification under high C/N and low C/N conditions.
View Article and Find Full Text PDFEnergy-exergy and enviro-economic analysis of water-cooled brazed plate building-integrated condenser for cooling appliances in dwellings.
Environ Sci Pollut Res Int
January 2025
Department of Mechanical Engineering, Sree Chitra Thirunal College of Engineering, Pappanamcode, Thiruvananthapuram, India.
Globally, domestic refrigerators account for over 13% of the total energy consumption in residential buildings. The brazed plate water-cooled condenser (BPWCC) is compact in size and an attractive option to reduce the energy consumption of refrigerators using domestic water tanks. This study evaluated the performance of a household refrigerator with a secondary refrigerant calorimeter and BPWCC, using an appropriate experimental setup.
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