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Determination of urinary deanol-N-oxide excretion profiles after ingestion of nutritional supplements containing deanol.
Drug Test Anal
December 2023
Center for Preventive Doping Research - Institute of Biochemistry, German Sport University Cologne, Cologne, Germany.
2-(Dimethylamino)ethan-1-ol (Deanol) is a widely produced chemical used by both industry and consumers in a variety of applications. Meclofenoxate, a stimulant classified on the World Anti-Doping Agency Prohibited List, metabolizes into deanol and, presumably, its main metabolite deanol-N-oxide. Hence, using liquid chromatography-tandem mass spectrometry, a quantitative detection method for deanol-N-oxide in urine was developed.
View Article and Find Full Text PDFApplication of ,-Dimethylethanolamine as a One-Carbon Synthon for the Synthesis of Pyrrolo[1,2-]quinoxalines, Quinazolin-4-ones, and Benzo[4,5]imidazoquinazolines [5 + 1] Annulation.
J Org Chem
November 2022
Institute of Advanced Studies and School of Pharmaceutical Sciences, Taizhou University, Jiaojiang, 318000 Zhejiang, Taizhou, China.
The synthesis of -heterocycles composes a significant part of synthetic chemistry. In this report, a Cu(II)-catalyzed green and efficient synthesis of pyrrolo[1,2-]quinoxaline, quinazolin-4-one, and benzo[4,5]imidazoquinazoline derivatives was developed, employing -dimethylethanolamine (DMEA) as a C1 synthon. Green oxidant O is critical in these transformations, facilitating the formation of a key intermediate─a reactive iminium ion.
View Article and Find Full Text PDFQuantification of Very-Long-Chain and Branched-Chain Fatty Acids in Plasma by Liquid Chromatography-Tandem Mass Spectrometry.
Methods Mol Biol
September 2022
Department of Pathology, University of Utah, Salt Lake City, UT, USA.
Peroxisomal disorders are a heterogeneous group of genetic disorders caused by impaired peroxisomal biogenesis or by defects in single peroxisomal proteins. The most common peroxisomal disorders are Zellweger spectrum disorders (ZSDs), due to pathogenic variants in one of the 13 PEX genes, and X-linked adrenoleukodystrophy/adrenomyeloneuropathy (X-ALD/AMN), due to pathogenic variants in ATP-binding cassette transporter type D1 (ABCD1) gene. Peroxisomes perform multiple essential cellular functions, including β-oxidation of very-long-chain fatty acids (VLCFAs), pristanic acid and some bile acid intermediates, and α-oxidation of phytanic acid.
View Article and Find Full Text PDFA Greener Route to Blue: Solid-State Synthesis of Phthalocyanines.
Angew Chem Int Ed Engl
October 2022
Department of Bioproducts and Biosystems, Aalto University, 02150, Espoo, Finland.
Phthalocyanines are important organic dyes with a broad applicability in optoelectronics, catalysis, sensing and nanomedicine. Currently, phthalocyanines are synthetized in high boiling organic solvents, like dimethylaminoethanol (DMAE), which is a flammable, corrosive, and bioactive substance, miscible with water and harmful to the environment. Here we show a new solid-state approach for the high-yielding synthesis of phthalocyanines, which reduces up to 100-fold the amount of DMAE.
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