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ACS Nano
January 2025
Department of Biomedical Engineering, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong 999077, China.
Real-time monitoring of hemodynamics is crucial for diagnosing disorders within implanted vascular grafts and facilitating timely treatment. Integrating vascular grafts with advanced flexible electronics offers a promising approach to developing smart vascular grafts (SVGs) capable of continuous hemodynamic monitoring. However, most existing SVG devices encounter significant challenges in practical applications, particularly regarding biomechanical compatibility and the effective evaluation of vascular status.
View Article and Find Full Text PDFACS Sens
January 2025
Sensor Engineering Department, Faculty of Science and Engineering, Maastricht University, P.O. Box 616, 6200 MDMaastricht, The Netherlands.
Malaria is a major public healthcare concern worldwide, representing a leading cause of death in specific regions. The gold standard for diagnosis is microscopic analysis, but this requires a laboratory setting, trained staff, and infrastructure and is therefore typically slow and dependent on the experience of the technician. This study introduces, for the first time, a biomimetic sensing platform for the direct detection of the disease.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
Porous silicon (pSi) has gained substantial attention as a versatile material for various biomedical applications due to its unique structural and functional properties. Initially used as a semiconductor material, pSi has transitioned into a bioactive platform, enabling its use in drug delivery systems, biosensing, tissue engineering scaffolds, and implantable devices. This review explores recent advancements in macrostructural pSi, emphasizing its biocompatibility, biodegradability, high surface area, and tunable properties.
View Article and Find Full Text PDFACS Appl Mater Interfaces
January 2025
Department of Chemistry, Yeungnam University, 280 Daehak-ro, Gyeongsan-si, Gyeongsangbuk-do 38541, Republic of Korea.
Recent studies have reported that the cause and progression of many diseases are closely related to complex and diverse gene regulation involving multiple microRNAs (miRNAs). However, most existing methods for miRNA detection typically deal with one sample at a time, which limits the achievement of high diagnostic accuracy for diseases associated with multiple gene dysregulations. Herein, we develop a liquid flow-based microfluidic optical assay for the simple and reliable detection of two different target miRNAs simultaneously at room temperature without any enzymatic reactions.
View Article and Find Full Text PDFACS Chem Neurosci
January 2025
School of Medicine, Shanghai University, Shanghai 200444, China.
Noninvasive imaging of β-amyloid is pivotal for the early diagnosis of Alzheimer's disease (AD). While single imaging methods have been extensively studied for detecting Aβ over the past decade, dual-modal probes have received scant attention. In this study, we synthesized and assessed a series of half-curcumin probes, among which demonstrated a high affinity and selectivity for Aβ aggregates.
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