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SGLT1 Inhibition Attenuates Apoptosis in Diabetic Cardiomyopathy via the JNK and p38 Pathway.
Front Pharmacol
January 2021
Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, China.
Recent studies have revealed that a novel selective sodium-glucose cotransporter 1 (SGLT1) inhibiton has shown beneficial effects in cardiovascular diseases. However, the question of whether SGLT1 inhibition influences diabetic cardiomyopathy (DCM) remains unanswered. In this study, we investigated the influence and underlying mechanism of SGLTI inhibition on DCM.
View Article and Find Full Text PDFContemporary choice of glucose lowering agents in heart failure patients with type 2 diabetes.
Acta Cardiol
June 2020
Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Belgium.
The choice of glucose lowering agent in heart failure (HF)-patients can have a strong effect on HF-related adverse events, with some classes increasing and other classes reducing the risk. Little data is available about the choice of glucose lowering agents in HF-patients with type-2-diabetes. We performed a cross-sectional single centre point analysis of all patients with both a diagnoses of HF and type-2-diabetes followed in a tertiary HF-clinic.
View Article and Find Full Text PDFAstagalus Polysaccharide Attenuates Murine Colitis through Inhibiton of the NLRP3 Inflammasome.
Planta Med
January 2017
Institute of Immunology, PLA, Third Military Medical University, Chongqing, China.
polysaccharide is an important bioactive component of , an herb used in traditional Chinese medicine for treating inflammatory bowel disease. The NOD-like receptor protein 3 inflammasome plays an important role in the pathogenesis of inflammatory bowel disease. However, little is known about the role of NOD-like receptor protein 3 inflammasome in polysaccharide-treated mice with experimental colitis.
View Article and Find Full Text PDFα-Glucosidase inhibiton and antiglycation activity of laccase-catalyzed catechin polymers.
J Agric Food Chem
May 2013
Department of Foods and Nutrition, Kookmin University, Seoul, Korea.
Catechin polymers were produced by laccase (12 U/mL) in a mixture of sodium acetate buffer (1% (+)-catechin, 100 mM, pH 5) and methanol (buffer:methanol = 95:5, v/v). The freeze-dried catechin polymers were recovered from the precipitate after dialysis followed by centrifugation. Catechin polymers extracted with 20% ethanol had potent inhibitory activity against α-glucosidase with an IC50 value of 4 μg/mL, and they were present as a mixture of dimers, trimers, and tetramers.
View Article and Find Full Text PDFTRPM8 activation attenuates inflammatory responses in mouse models of colitis.
Proc Natl Acad Sci U S A
April 2013
Department of Physiology and Pharmacology, Inflammation Research Network, Snyder Institute for Chronic Diseases, University of Calgary, Calgary, AB, Canada T2N 4N1.
Transient Receptor Potential Melastatin-8 (TRPM8), a recently identified member of the transient receptor potential (TRP) family of ion channels, is activated by mild cooling and by chemical compounds such as the supercooling agent, icilin. Since cooling, possibly involving TRPM8 stimulation, diminishes injury-induced peripheral inflammation, we hypothesized that TRPM8 activation may also attenuate systemic inflammation. We thus studied the involvement of TRPM8 in regulating colonic inflammation using two mouse models of chemically induced colitis.
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