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Withdrawal from 3alpha-OH-5alpha-pregnan-20-One using a pseudopregnancy model alters the kinetics of hippocampal GABAA-gated current and increases the GABAA receptor alpha4 subunit in association with increased anxiety.
J Neurosci
July 1998
Department of Neurobiology and Anatomy, Allegheny University of the Health Sciences, Eastern Pennsylvania Psychiatric Institute, Philadelphia, Pennsylvania 19129, USA.
In the present study, we have characterized properties of steroid withdrawal using a pseudopregnant rat model. This paradigm results in increased production of endogenous progesterone from ovarian sources and as such is a useful physiological model. "Withdrawal" from progesterone induced by ovariectomy on day 12 of pseudopregnancy resulted in increased anxiety, as determined by a decrease in open arm entries on the elevated plus maze compared to control rats and pseudopregnant animals not undergoing withdrawal.
View Article and Find Full Text PDFWithdrawal from the endogenous steroid progesterone results in GABAA currents insensitive to benzodiazepine modulation in rat CA1 hippocampus.
J Neurophysiol
July 1995
Department of Pharmacology, Zeneca Pharmaceuticals, Wilmington, Delaware 19897, USA.
1. The withdrawal properties of the endogenous steroid progesterone (P) were tested in female rats as a function of benzodiazepine modulation of gamma-aminobutyric acid-A (GABAA)-gated current with the use of the whole cell patch-clamp technique on acutely dissociated CA1 hippocampal neurons. In a previous study, this steroid was shown to exhibit withdrawal properties, behaviorally.
View Article and Find Full Text PDFGABA-mediated positive autofeedback loop controls horizontal cell kinetics in tiger salamander retina.
J Neurosci
July 1992
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Horizontal cells (HCs) appear to release, and also to be sensitive to, GABA. The external GABA concentration is increased with depolarization of the HC membrane via an electrogenic GABA transporter. This extracellular GABA opens a GABAA-gated Cl- channel in the HC membrane.
View Article and Find Full Text PDFModulation of GABAA-gated C1- currents in nigral neurons in slices.
Adv Biochem Psychopharmacol
September 1992
Fidia-Georgetown Institute for the Neurosciences, Georgetown University, Washington, D.C. 20007.
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