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Tapered Submerged Implants in an Augmented Posterior Maxilla After Oroantral Fistula Closure.
J Craniofac Surg
November 2024
Department of Oral and Maxillofacial Surgery, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Korea.
Dental implantation in the posterior maxilla is challenging due to anatomic proximity to the sinuses, relative bone quality, and pre-existing sinus diseases. An oroantral fistula (OAF) acts as a pathologic pathway of bacteria and can cause sinus infections and complicate dental implant management. Bony augmentation between the sinus floor mucosa and the oral mucosa at the OAF closure site is another critical consideration.
View Article and Find Full Text PDFCenobamate as add-on treatment for SCN8A developmental and epileptic encephalopathy.
Epilepsia
January 2025
Department of Epilepsy Genetics and Personalized Medicine, Danish Epilepsy Center, Dianalund, Denmark.
Objectives: Developmental and epileptic encephalopathies (DEEs) caused by pathogenic variants in SCN8A are associated with difficult-to-treat and early-onset seizures, developmental delay/intellectual disability, impaired quality of life, and increased risk of early mortality. High doses of sodium channel blockers are typically used to treat SCN8A-DEE caused by gain-of-function (GoF) variants. However, seizures are often drug resistant, and only a few patients achieve seizure freedom.
View Article and Find Full Text PDFSystems immunology integrates the complex endotypes of recessive dystrophic epidermolysis bullosa.
Nat Commun
January 2025
National Institute of Health and Medical Research (INSERM) UMRS-976 HIPI, Paris Cité University, Saint-Louis Hospital, 75010, Paris, France.
Endotypes are characterized by the immunological, inflammatory, metabolic, and remodelling pathways that explain the mechanisms underlying the clinical presentation (phenotype) of a disease. Recessive dystrophic epidermolysis bullosa (RDEB) is a severe blistering disease caused by COL7A1 pathogenic variants. Although underscored by animal studies, the endotypes of human RDEB are poorly understood.
View Article and Find Full Text PDFClinical characteristics and autonomic balance in patients with burning mouth syndrome: A retrospective chart review.
Medicine (Baltimore)
November 2024
Division of Digestive Diseases, Department of Korean Internal Medicine, Kyung Hee University Korean Medicine Hospital, Seoul, Republic of Korea.
This study aimed to identify the clinical characteristics of patients with burning mouth syndrome (BMS) according to the low frequency/high frequency (LF/HF) ratio in the heart rate variability test and to evaluate the potential of the LF/HF ratio as an indicator for the diagnostic or predictive assessment of patients with BMS. A total of 469 patients with BMS who visited the Oral Diseases Clinic of Kyung Hee University Korean Medicine Hospital between January 1, 2018, and December 31, 2022, were included in the study. The patients were asked to rate their tongue pain on a visual analog scale before and after treatment.
View Article and Find Full Text PDFSinomenine attenuates uremia vascular calcification by miR-143-5p.
Sci Rep
January 2025
Department of Nephrology, Yiyang Central Hospital, 118 Kangfubei Road, Yiyang, 413000, Hunan, China.
Vascular calcification is considered to be a killer of the cardiovascular system, involved inflammation and immunity. There is no approved therapeutic strategy for the prevention of vascular calcification. Sinomenine exhibited anti-inflammatory and immunosuppressive effects.
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