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Less cytotoxic phthalocyanine derivative promotes in vitro wound healing compared to chlorhexidine.
J Appl Biomater Funct Mater
January 2025
Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo, Bauru, Brazil.
The use of adjunct chemical substances in the early postoperative period of periodontal surgical procedures is recommended due to the potential risk of trauma in the operated area. Chlorhexidine digluconate mouthwash is widely used but can cause adverse effects. Phthalocyanine derivatives are being studied as an alternative, demonstrating good antimicrobial activity, especially in the self-activated form, which does not require additional light or chemicals.
View Article and Find Full Text PDFOutcomes of surgical patients in a tertiary ICU with incidental COVID-19 in comparison with COVID-19 naïve patients.
S Afr J Surg
December 2024
Department of Surgery, Tygerberg Hospital, Stellenbosch University, South Africa.
Background: COVID-19 was first identified in Wuhan, China, in December 2019, where it spread over a wide geographic area until it reached the status of a pandemic in 2020. We postulated that patients who were diagnosed with incidental COVID-19, and underwent surgery, did not have a worse outcome due to the COVID-19 virus compared to their counterparts who did not have the virus.
Methods: This retrospective study included surgical patients (COVID-19 incidentals and COVID-19 negatives) who were admitted to the surgical intensive care unit (SICU) at Tygerberg Academic Hospital between 1 May 2020 and 31 December 2021.
Comparative study of polymeric nanoparticles and traditional agents in dental implant decontamination.
J Appl Biomater Funct Mater
January 2025
Faculty of Dentistry, Department of Periodontics, Complutense University of Madrid, Madrid, Spain.
Peri-implant diseases, such as peri-implantitis, affect up to 47% of dental implant recipients, primarily due to biofilm formation. Current decontamination methods vary in efficacy, prompting interest in polymeric nanoparticles (NPs) for their antimicrobial and protein-specific cleaning properties. This study evaluated the efficacy of polymeric nanoparticles (NPs) in decontaminating titanium dental implants by removing proteinaceous pellicle layers and resisting recontamination.
View Article and Find Full Text PDFA comparison of the persuasiveness of human and ChatGPT generated pro-vaccine messages for HPV.
Front Public Health
January 2025
CAS Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences, Beijing, China.
Introduction: Public health messaging is crucial for promoting beneficial health outcomes, and the latest advancements in artificial intelligence offer new opportunities in this field. This study aimed to evaluate the effectiveness of ChatGPT-4 in generating pro-vaccine messages on different topics for Human Papillomavirus (HPV) vaccination.
Methods: In this study ( = 60), we examined the persuasive effect of pro-vaccine messages generated by GPT-4 and humans, which were constructed based on 17 factors impacting HPV vaccination.
Comparative efficacy of repurposed drugs lopinavir-ritonavir and darunavir-ritonavir in hospitalised COVID-19 patients: insights from a tertiary centre cohort.
Front Cell Infect Microbiol
January 2025
Department of Infectious Diseases, Infectious Diseases and Pulmonology Clinical Hospital, Timisoara, Romania.
Background: Drug repurposing has become a widely adopted strategy to minimise research time, costs, and associated risks. Combinations of protease inhibitors such as lopinavir and darunavir with ritonavir have been repurposed as treatments for COVID-19. Although lopinavir-ritonavir (LPV/r) and darunavir-ritonavir (DRV/r) have shown efficacy against COVID-19, the results in human studies have been inconsistent.
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