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Intussusception in children with celiac disease.
J Family Med Prim Care
November 2024
Pediatric Department, Jeddah, Saudi Arabia.
Celiac disease (CD) is a chronic illness. Blood testing for tissue transglutaminase antibodies is the initial screening test for the diagnosis of CD, and upper gastrointestinal endoscopy and duodenal/jejunal biopsy are used to confirm CD. Intussusception (IS) is the process in which a proximal segment of the bowel invaginates through the lumen of a distal segment.
View Article and Find Full Text PDFAssessment of neonatal glycaemic status and comorbidities in infants of diabetic mothers admitted to the neonatal care unit of Al-Ramadi Teaching Hospital for maternity and childhood, Iraq.
J Pak Med Assoc
October 2024
Department of Paediatrics, Mustansiriyah University, Baghdad, Iraq.
Objective: To assess neonatal and maternal characteristics, glycaemic status and comorbidities in the neonates of diabetic mothers.
Methods: The cross-sectional study was conducted from October 2021 to May 2022 at the Department of Physiology, College of Medicine, University of Mustansiriyah, Baghdad, Iraq, and comprised healthy women. Samples were raised by simple random technique.
Patterns and unique features of infantile cholestasis among Arabs.
Front Pediatr
July 2024
College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Background: Most of the literature on infantile cholestasis (IC) originated from Caucasian and Asian populations. The differential diagnosis of IC is very broad, and identification of etiology is challenging to clinicians because the list includes many entities with overlapping clinical, biochemical, and histological features. Thus, a structured, stepwise diagnostic approach is required to help early recognition and prompt evaluation and management of treatable causes of cholestasis.
View Article and Find Full Text PDFCase Report: A case of Dubin-Johnson syndrome in a newborn.
Front Pediatr
July 2024
Department of General Surgery, Hainan Women and Children's Medical Center, Hainan Women and Children's Medical Center, Haikou, Hainan, China.
Background: Dubin-Johnson Syndrome (DJS) is a rare autosomal recessive genetic disorder, with most cases presenting in adolescence, but rare in newborns.
Objective: To investigate the clinical characteristics and treatment outcomes of DJS in a newborn.
Methods: We present the clinical features of a newborn diagnosed with DJS through molecular genetic testing.
Article Synopsis
- MRP2 is an important protein that helps export substances out of liver cells and can affect how cancer treatments work; its dysfunction is linked to Dubin-Johnson Syndrome and increased liver damage risk from certain drugs.
- Researchers used cryogenic electron microscopy to visualize MRP2 in three different forms: autoinhibited, substrate-bound, and ATP-bound, demonstrating that it operates through ATP-driven changes in shape.
- The structure analysis shows that MRP2 has a regulatory domain that selectively allows certain substrates to initiate transport, helping to explain its role in multidrug resistance by recognizing a variety of compounds.
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