Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
A rare case of epithelioid angiosarcoma.
Port J Card Thorac Vasc Surg
May 2024
Vascular Surgery Department, Centro Hospitalar do Tâmega e Sousa, Penafiel, Portugal.
Epithelioid angiosarcoma is a rare high-grade vascular neoplasm with a poor prognosis. We present an anticoagulated 77-year-old man, with a history of popliteal/soleal vein thrombosis in the previous month, complaining of ipsilateral persistent lower limb pain and claudication. Absent popliteal/distal pulses prompted an arterial doppler ultrasound (DUS), revealing thrombosis of the distal superficial femoral artery and a popliteal mass.
View Article and Find Full Text PDFSingle-cell division tracing and transcriptomics reveal cell types and differentiation paths in the regenerating lung.
Nat Commun
March 2024
Division of Applied Functional Genomics, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Understanding the molecular and cellular processes involved in lung epithelial regeneration may fuel the development of therapeutic approaches for lung diseases. We combine mouse models allowing diphtheria toxin-mediated damage of specific epithelial cell types and parallel GFP-labeling of functionally dividing cells with single-cell transcriptomics to characterize the regeneration of the distal lung. We uncover cell types, including Krt13 basal and Krt15 club cells, detect an intermediate cell state between basal and goblet cells, reveal goblet cells as actively dividing progenitor cells, and provide evidence that adventitial fibroblasts act as supporting cells in epithelial regeneration.
View Article and Find Full Text PDFIs Dissection and Preservation of Adherent Popliteal Vessels From a Posterior Soft Tissue Mass Associated With a Higher Proportion of Local Recurrence in Patients With a Distal Femoral Osteosarcoma?
Clin Orthop Relat Res
November 2023
Orthopaedic Department, Cairo University, Cairo, Egypt.
Background: In patients who have osteosarcoma of the distal femur, there is concern that when dissecting the popliteal vessels from the posterior soft tissue extent of the tumor, a less-than-wide margin of resection may be achieved depending on the extent of the posterior soft tissue mass. Surgeons have little information to guide them when deciding whether dissecting the popliteal vessels in a patient in whom the vessels are in direct contact with a posterior mass will result in an increased likelihood of local recurrence compared with patients in whom the popliteal vessels are not in contact with the tumor mass.
Questions/purposes: (1) Is dissecting the adherent popliteal artery and vein away from the posterior soft tissue extent of a distal femoral osteosarcoma by stripping them from their adventitia associated with an increased risk of local recurrence compared with patients in whom there is normal tissue between the tumor and vessels? (2) Is there an association with the type of tumor resection and the development of chest metastases and overall survivorship in this anatomic location?
Methods: We retrospectively studied our patient database.
Outcomes of Planned Marginal and Wide Resection of Sarcomas Associated with Major Vascular Structures in Extremities.
Indian J Surg Oncol
June 2022
Department of Orthopaedics and Traumatology, Dr. Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital, Demetevler Mahallesi, Vatan Cad., Yenimahalle, Ankara, 06200 Turkey.
Bone and soft tissue sarcomas of lower and upper extremities may sometimes be in close contact with neurovascular structures. In such cases, it is controversial that whether en bloc resection and vascular reconstruction to reach wider surgical margins or planned marginal resection with the help of adjuvant therapies should be preferred. This study aimed to determine surgical and oncological outcomes of planned marginal and wide resection of extremity sarcomas that are associated with major vascular structures in the extremities.
View Article and Find Full Text PDFAn update on the imaging of diaphyseal aclasis.
Skeletal Radiol
October 2021
Department of Radiology, Royal National Orthopaedic Hospital, Stanmore, UK.
Solitary osteochondromas are common, benign hyaline cartilage-capped exostoses that primarily arise from the metaphyses of long and flat bones. Diaphyseal aclasis is an autosomal dominant condition resulting from EXT1 or EXT2 gene mutations and is characterized by multifocal osteochondromas. These can result in a wide spectrum of complications, such as skeletal deformity, neurological and vascular complications, adventitial bursa formation, fracture, and rarely malignant transformation to peripheral chondrosarcoma.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!