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Insulin resistance compromises midbrain organoid neuronal activity and metabolic efficiency predisposing to Parkinson's disease pathology.
J Tissue Eng
January 2025
Developmental and Cellular Biology, Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Growing evidence indicates that type 2 diabetes (T2D) is associated with an increased risk of developing Parkinson's disease (PD) through shared disease mechanisms. Studies show that insulin resistance, which is the driving pathophysiological mechanism of T2D plays a major role in neurodegeneration by impairing neuronal functionality, metabolism and survival. To investigate insulin resistance caused pathological changes in the human midbrain, which could predispose a healthy midbrain to PD development, we exposed iPSC-derived human midbrain organoids from healthy individuals to either high insulin concentration, promoting insulin resistance, or to more physiological insulin concentration restoring insulin signalling function.
View Article and Find Full Text PDFConstruction of functional tissue-engineered microvasculatures using circulating fibrocytes as mural cells.
J Tissue Eng
January 2025
Department of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Mural cells are essential for maintaining the proper functions of microvasculatures. However, a key challenge of microvascular tissue engineering is identifying a cellular source for mural cells. We showed that , circulating fibrocytes (CFs) can (1) shear and stabilize the microvasculatures formed by vascular endothelial cells (VECs) in a collagen gel, (2) form gap junctions with VECs and (3) induce basement membrane formation.
View Article and Find Full Text PDFA systematic review of associations between the environment, DNA methylation, and cognition.
Environ Epigenet
December 2024
Institute of Clinical Science B, Royal Victoria Hospital, Centre for Public Health, Queens' University Belfast, Grosvenor Rd, Belfast BT12 6BA, United Kingdom.
The increasing prevalence of neurodegenerative diseases poses a significant public health challenge, prompting a growing focus on addressing modifiable risk factors of disease (e.g. physical inactivity, mental illness, and air pollution).
View Article and Find Full Text PDFUnveiling hotspots of emerging research in the miRNA-related mechanism underlying cancer through comprehensive bibliometric analysis with implications for precision medicine and non-invasive diagnostics.
Front Oncol
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Department of Colorectal Hernia Surgery, Binzhou Medical University Hospital, Binzhou, Shandong, China.
Background And Objective: MicroRNAs (miRNAs) are implicated in cancer by exerting roles in tumor growth, metastasis, and even drug resistance. The general trends of miRNA research in diverse cancers are not fully understood. In this work, miRNA-related research in colorectal cancer, prostate cancer, leukemia, and brain tumors was analyzed in search of key research trends with clinical potential.
View Article and Find Full Text PDFA portable EEG signal acquisition system and a limited-electrode channel classification network for SSVEP.
Front Neurorobot
January 2025
College of Engineering, Qufu Normal University, Rizhao, China.
Brain-computer interfaces (BCIs) have garnered significant research attention, yet their complexity has hindered widespread adoption in daily life. Most current electroencephalography (EEG) systems rely on wet electrodes and numerous electrodes to enhance signal quality, making them impractical for everyday use. Portable and wearable devices offer a promising solution, but the limited number of electrodes in specific regions can lead to missing channels and reduced BCI performance.
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