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Manifestations of the archaic in character within the analytic field: From memories in behaviour to chronic and acute enactments.
Int J Psychoanal
December 2024
Brazilian Psychoanalytic Society of Campinas, Campinas, Brazil.
The objective of this paper is to discuss the ways in which primitive aspects of the mind, in particular, the archaic elements of character, become manifest within the analytic field. After a review of the concept, it is proposed that a "normal" character manifests through memories in behaviours/feelings, which seek the object to satisfy their needs. The characterological structure keeps primitive traumatic inscriptions under control.
View Article and Find Full Text PDFComparative Structural and Biophysical Investigation of Toxin I (LyeTx I) and Its Analog LyeTx I-b.
Antibiotics (Basel)
January 2025
Departamento de Química, Faculdade de Ciências Exatas, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Campus JK, Diamantina 39100-000, MG, Brazil.
This study investigates the structural and biophysical properties of the wild-type antimicrobial peptide LyeTx I, isolated from the venom of the spider , and its analog LyeTx I-b, designed to enhance antibacterial activity, selectivity, and membrane interactions by the acetylation and increased amphipathicty. : To understand the mechanisms behind these enhanced properties, comparative analyses of the structural, topological, biophysical, and thermodynamic aspects of the interactions between each peptide and phospholipid bilayers were evaluated. Both peptides were isotopically labeled with H-Ala and N-Leu to facilitate structural studies via NMR spectroscopy.
View Article and Find Full Text PDFPhosphorylation of PA at serine 225 enhances viral fitness of the highly pathogenic H5N1 avian influenza virus in mice.
Vet Microbiol
January 2025
Key Laboratory of Avian Bioproducts Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China; Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonosis, College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China; Key Laboratory of Prevention and Control of Biological Hazard Factors (Animal Origin) for Agri-food Safety and Quality, Ministry of Agriculture of China (26116120), College of Veterinary Medicine, Yangzhou University, Yangzhou, Jiangsu, China.
Currently, there is increasing spillover of highly pathogenic H5N1 avian influenza virus (AIV) to mammals, raising a concern of pandemic threat about this virus. Although the function of PA protein of the influenza virus is well understood, the understanding of how phosphorylation regulates this protein and influenza viral life cycle is still limited. We previously identified PA S225 as the phosphorylation site in the highly pathogenic H5N1 AIV.
View Article and Find Full Text PDFLigand Inter-Relation Analysis Via Graph Theory Predicts Macrophage Response.
Adv Mater
December 2024
Department of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of Korea.
Graph theory has been widely used to quantitatively analyze complex networks of molecules, materials, and cells. Analyzing the dynamic complex structure of extracellular matrix can predict cell-material interactions but has not yet been demonstrated. In this study, graph theory-based mathematical modeling of RGD ligand graph inter-relation is demonstrated by differentially cutting off RGD-to-RGD interlinkages with flexibly conjugated magnetic nanobars (MNBs) with tunable aspect ratio.
View Article and Find Full Text PDFTumor-mimetic hydrogel stiffness regulates cancer stemness properties in H-Ras-transformed cancer model cells.
Biochem Biophys Res Commun
January 2025
Graduate School of Life Science, Hokkaido University, N21 W11, Kita-ku, Sapporo, 001-0021, Japan; Department of Cancer Pathology, Faculty of Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo, 060-8638, Japan; Institute for Chemical Reaction Design and Discovery (WPI-ICReDD), Hokkaido University, N21 W10, Kita-ku, Sapporo, 001-0021, Japan. Electronic address:
Article Synopsis
- Cancer stem cells (CSCs) contribute to therapy resistance and cancer recurrence, making it essential to develop treatment strategies that specifically target CSCs.
- Previous research showed that glioblastoma cells can be transformed into CSCs when cultured on double-network hydrogels, simulating tumor stiffness.
- In this study, H-Ras-transformed fibroblasts cultured on a hydrogel with 10 kPa stiffness exhibited increased expression of stemness markers, suggesting that the stiffness of tumor tissues plays a crucial role in the generation of CSCs through certain cellular mechanisms.
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