Both streptomycin and dihydrostreptomycin in large doses produced neuromuscular blockade in different types of skeletal nerve-muscle preparations. Streptomycin had a quicker, more marked and a longer-lasting action than dihydrostreptomycin. Neostigmine reversed a partial block of streptomycin, but a complete neuromuscular block remained unaffected. Calcium ions antagonized the neuromuscular block of streptomycin rapidly but incompletely.
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| http://dx.doi.org/10.1111/j.1476-5381.1960.tb00271.x | DOI Listing |
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