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Food hardness preference reveals multisensory contributions of fly larval gustatory organs in behaviour and physiology.
PLoS Biol
January 2025
Department of Biology, University of Fribourg, Fribourg, Switzerland.
Article Synopsis
- Food is a multisensory experience, relying on visuals, taste, smell, and, surprisingly, texture to assess nutritional value and safety.
- Despite being overlooked, texture offers crucial information about food's physical properties, like hardness and liquidity.
- Recent findings show that some sensory neurons are not limited to specific stimuli; instead, they can respond broadly, indicating greater sensory complexity than previously thought.
This study used coal combustion products (CCP) with different calcium contents to replace partial aluminate cement (AC) in equal amounts, and studied the effect of calcium contents on the setting time and early compressive strength of AC. The setting time and early compressive strength were further regulated by adding retarder. The results showed that the higher the calcium content of CCP (CCP2 contains higher calcium content), the shorter the setting time and the higher the 2 h compressive strength after replacing part of cement.
View Article and Find Full Text PDFfragSMILES as a chemical string notation for advanced fragment and chirality representation.
Commun Chem
January 2025
Dipartimento di Farmacia-Scienze del Farmaco, Università degli Studi di Bari Aldo Moro, Bari, Italy.
Generative models have revolutionized de novo drug design, allowing to produce molecules on-demand with desired physicochemical and pharmacological properties. String based molecular representations, such as SMILES (Simplified Molecular Input Line Entry System) and SELFIES (Self-Referencing Embedded Strings), have played a pivotal role in the success of generative approaches, thanks to their capacity to encode atom- and bond- information and ease-of-generation. However, such 'atom-level' string representations could have certain limitations, in terms of capturing information on chirality, and synthetic accessibility of the corresponding designs.
View Article and Find Full Text PDFTime persistence of the fMRI resting-state functional brain networks.
J Neurosci
January 2025
The Gonda Multidisciplinary Brain Research Center, Bar Ilan University, Ramat Gan, 52900, Israel
Time persistence is a fundamental property of many complex physical and biological systems; thus understanding the phenomenon in the brain is of high importance. Time persistence has been explored at the level of stand-alone neural time-series, but since the brain functions as an interconnected network, it is essential to examine time persistence at the network level. Changes in resting-state networks have been previously investigated using both dynamic (i.
View Article and Find Full Text PDFCholesterol affects the binding of proteins to phosphatidic acid without influencing its ionization properties.
J Lipid Res
January 2025
Department of Biological Sciences, Kent State University, P.O. Box 5190, Kent, OH 44242, USA. Electronic address:
Phosphatidic acid (PA) through its unique negatively charged phosphate headgroup binds to various proteins to modulate multiple cellular events. To perform such diverse signaling functions, the ionization and charge of PA's headgroup relies on the properties of vicinal membrane lipids and changes in cellular conditions. Cholesterol has conspicuous effects on lipid properties and membrane dynamics.
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