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Assessment of Non-Vitamin K Antagonist Oral Anticoagulant Dosing Patterns in Turkish Patients with Non-Valvular Atrial Fibrillation: A Multicenter, Cross-Sectional Study with Insights from the ASPECT-NOAC Study.
Turk Kardiyol Dern Ars
December 2024
Department of Cardiology, İstanbul Medipol University Bahcelievler Hospital, İstanbul, Türkiye.
Objective: We aimed to assess the real-world label adherence of non-vitamin K antagonist oral anticoagulant (NOAC) dosing patterns, including apixaban, edoxaban, and rivaroxaban, in Turkish patients with atrial fibrillation.
Methods: This was an observational, prospective, cross-sectional, multicenter study. Patients with atrial fibrillation (AF) who were prescribed NOACs within the last 4 months were recruited from 34 cardiology clinics in Türkiye.
[The follow-up examination of children with breath-holding spells].
Zh Nevrol Psikhiatr Im S S Korsakova
November 2024
Belgorod Children's Regional Hospital, Belgorod, Russia.
Article Synopsis
- The study focused on children experiencing breath-holding spells to analyze their developmental features and health status.
- A total of 72 primary school children were evaluated using various clinical and psychological assessment tools, revealing significant health issues.
- Results indicated that nearly half of the children with breath-holding spells may develop further problems such as gastrointestinal issues, headaches, and anxiety disorders later on.
Combined left atrial appendage occlusion and catheter ablation procedure for left atrial arrhythmias: A real-world, propensity-matched analysis.
J Cardiovasc Electrophysiol
December 2024
Heart & Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Introduction: Real-world studies comparing safety and efficacy of combined percutaneous left atrial appendage occlusion (LAAO) and catheter ablation (CA) to LAAO alone are limited.
Methods: Patients from a large US hospital system undergoing combined LAAO and left-atrial CA from 8/2020 to 2/2024 were retrospectively analyzed and compared to a control group undergoing LAAO alone. Controls were identified using a 1:2 propensity score match based on LAAO device type (Watchman FLX vs.
Clinical predictors of warfarin-associated bleeding: A case-control study.
Trop Doct
October 2024
Additional Professor, Department of Cardiothoracic and Vascular Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.
Despite the advent of directly acting oral anticoagulants, warfarin is still widely used in resource-poor settings. Bleeding as a result of warfarin overdosage is common and risk factors seem to vary between patient populations. Predictors of bleeding in patients using warfarin were studied using a case-control design.
View Article and Find Full Text PDFCathepsin B Nuclear Flux in a DNA-Guided "Antinuclear Missile" Cancer Therapy.
ACS Cent Sci
August 2024
Department of Therapeutic Radiology, Yale School of Medicine, New Haven, Connecticut 06510, United States.
Some antinuclear antibodies (ANAs) bind extracellular nucleic acids released into tumor environments and are pulled into the nuclei of live cancer cells through nucleoside salvage pathways, independent of tumor-specific surface antigens. Here we show that ANA nuclear penetration induces nuclear flux by the lysosomal protease cathepsin B and leverage this mechanism to design an antinuclear antibody-drug conjugate (ANADC) with cathepsin B-labile drug linker. The ANADC targets nucleic acid exhaust from necrotic tumors and crosses membrane barriers through nucleoside salvage as a DNA-seeking and tumor agnostic "antinuclear missile" cancer therapy.
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