The mutagenicity of 3-(4'-benzylidenamino)-5H-1,2,3-triazin[5,4-b]-indol-4-one derivatives, new compounds with considerable platelet antiaggregating activity, was assayed with the Ames test using the Salmonella typhimurium strains TA97, TA98, TA100 and TA102. The adaptive least-squares method (ALS method) was used to carry out a quantitative structure-activity relationship (QSAR) analysis. Three equations, based on 10 congeners, were found for strains TA97, TA98 and TA100. The results suggest that lipophilicity of the substituent decreases the mutagenicity of the series.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/0027-5107(92)90076-e | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Genotoxicity analysis of a flame retardant, aluminum diethylphosphinate.
Mutat Res Genet Toxicol Environ Mutagen
December 2024
School of Pharmacy, Federal Fluminense University, Niteroi, RJ, Brazil; National Institute for Alternative Technologies for the Detection, Toxicological Evaluation and Removal of Micropollutants and Radioactives (INCT-DATREM), UNESP, Institute of Chemistry, Araraquara, SP, Brazil.
Flame retardants, crucial for fire prevention, are used worldwide, but they are considered to be 'emerging contaminants' and may pose risks to human and environmental health. Aluminum diethyl phosphinate (ALPI) is a halogen-free flame retardant. To evaluate the toxicity of this compound, the following assays were performed: Salmonella/microsome mutagenicity assay; toxicity assays with two endpoints (mitochondrial dehydrogenase activity, plasma membrane integrity); micronucleus assay with human hepatoma cell line HepG2.
View Article and Find Full Text PDFHeterocyclic phytometabolites formononetin and arbutin prevent oxidative and alkylation-induced mutagenicity.
Toxicol Rep
December 2024
Department of Biophysics and Biometry, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Phenolic phytometabolites are promising bioactive compounds for management of genomic instability related diseases. Formononetin (FMN) and arbutin (ARB) are found in several plant sources. Our goal was to investigate the safety and efficacy of FMN and ARB using both standardized and alternative toxicogenetic methods.
View Article and Find Full Text PDFEvaluation of XQ528 tartrate on embryo-fetus developmental toxicity in SD rats and genotoxicity.
Drug Chem Toxicol
August 2024
Experimental Teaching Center, School of Basic Medical Sciences, Naval Medical University, Shanghai, China.
The effects of XQ528 tartrate on the embryonic and fetal development of fertile Sprague-Dawley (SD) rats, along with their embryos and littermates, were evaluated using an embryo-fetus developmental toxicity assay. fertile SD rats exhibited no significant general toxic effects when administered doses of 0.25, 1.
View Article and Find Full Text PDFAcute, subacute oral toxicity and Ames test of Py-mulin: an antibacterial drug candidate.
BMC Pharmacol Toxicol
January 2022
Key Laboratory of New Animal Drug Project, Gansu Province/Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture and Rural Affairs/Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agriculture Sciences, No. 335, Qilihe District, Lanzhou, 730050, People's Republic of China.
Background: Py-mulin is a new pleuromutilin derivative with potent antibacterial activities in vitro and in vivo, suggesting this compound may lead to a promising antibacterial drug after further development. The present study is aimed to evaluate the acute and subacute oral toxicity, and the genotoxicity with the standard Ames test according to standard protocols.
Methods: Acute oral toxicity of Py-mulin was determined using Kunming mice.
Mutagenicity evaluation to UV filters of benzophenone-6, benzophenone-8, and 4-methylbenzylidene camphor by Ames test.
PLoS One
December 2021
School of Energy & Environment, Southeast University, Nanjing, Jiangsu, China.
Benzophenone (BPs) and 4-Methylbenzylidene Camphor are used as ultraviolet (UV) filters to protect the skin and hair in personal care products. The discharging of the three chemicals may endanger the receiving water ecosystem. In the present study, the mutagenicity of BP-6, BP-8, and 4-Methylbenzylidene Camphor was tested using the Salmonella typhimurium reverse mutation test (Ames test) in the system with and without rat liver microsomal preparations (S9).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!