Objective: To report two cases of chronic neutropenic states successfully treated with granulocyte colony stimulating factor (G-CSF).
Clinical Features: A 23-year-old man with severe congenital cyclic neutropenia causing lifelong recurrent infections and consequent debilitation presented with intractable infected leg ulcers. A 56-year-old man with acquired idiopathic neutropenia presented with severe perianal infection and sepsis.
Intervention And Outcome: Both patients were successfully treated with recombinant G-CSF.
Conclusion: G-CSF is an agent with major clinical potential for the therapy of primary neutropenic states.
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| http://dx.doi.org/10.5694/j.1326-5377.1992.tb121518.x | DOI Listing |
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