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Neurotoxicity associated with colistin methanesulfonate treatment is enhanced by concomitant sevoflurane inhalation.
Toxicol Rep
June 2022
Division of Pharmacodynamics, Keio University Faculty of Pharmacy, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan.
Colistin methanesulfonate (CMS) is a cyclic polypeptide antibiotic with neurotoxic side effects. Sevoflurane (Sevo), an inhaled anesthetic, is known to enhance the non-depolarizing effect of neuromuscular relaxants; however, its mechanism of action is unclear. In this study, we investigated the augmentation effect of Sevo on CMS-induced neurotoxicity We prepared a sciatic nerve-skeletal muscle stimulation model using Sprague-Dawley male rats administered CMS with or without Sevo.
View Article and Find Full Text PDFThe role of the nAChR subunits α5, β2, and β4 on synaptic transmission in the mouse superior cervical ganglion.
Physiol Rep
March 2019
Division of Pathobiology of the Nervous System, Center for Brain Research, Medical University of Vienna, Vienna, Austria.
Article Synopsis
- The analysis of mouse superior cervical ganglion revealed that the majority of nicotinic acetylcholine receptors are made up of α3β4, α3β4α5, and α3β4β2 subunits.
- Experiments on α5β4-KO and α5β2-KO mice showed that while CAP amplitude remained the same, the stimulation threshold was significantly higher in α5β4-KO ganglia, suggesting altered synaptic transmission.
- Additionally, the blocking agent hexamethonium was most effective in α5β4-KO ganglia, indicating that a large population of receptors at the SCG neuron surface consists of α3β4α5, in contrast to earlier immunoprecipitation
Gas chromatographic mass analysis and further pharmacological actions of Cymbopogon proximus essential oil.
Drug Res (Stuttg)
September 2013
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
The present study reports Gas chromatographic mass analysis (GC-MS) as well as important biological activities of Cymbopogon proximus essential oil. The chemical composition of the essential oil of Cymbopogon proximus was investigated by GC-MS. Furthermore, the effects of Cymbopogon proximus essential oil on the cardiac parasympathetic ganglia in rats, the intra-tracheal pressure in guinea-pigs and on carrageenan-induced inflammation in the rats paw, were studied.
View Article and Find Full Text PDFThe contractile effect of anandamide in the guinea-pig small intestine is mediated by prostanoids but not TRPV1 receptors or capsaicin-sensitive nerves.
Basic Clin Pharmacol Toxicol
May 2013
Department of Pharmacology and Pharmacotherapy, University Medical School of Pécs, Pécs, Hungary.
Although exogenous and endogenous cannabinoid receptor agonists have well-documented inhibitory effects on gastrointestinal motility, a TRPV1 receptor-mediated excitatory action of anandamide (arachidonoyl ethanolamide, AEA) in the guinea-pig ileum strip has also been described. We used in vitro capsaicin desensitization for assessing the possible participation of sensory neurons in the contractile effect of anandamide on the guinea-pig whole ileum, as well as autonomic drugs and a cyclooxygenase inhibitor for characterizing this response. Isolated organ experiments were used with isotonic recording.
View Article and Find Full Text PDFThe impact of extracellular and intracellular Ca2+ on ethanol-induced smooth muscle contraction.
Acta Pharmacol Sin
October 2009
Department of Pharmacology, Faculty of Medicine, Cukurova University, 01330 Adana, Turkey.
Aim: To evaluate the impact of extracellular and intracellular Ca2+ on contractions induced by ethanol in smooth muscle.
Methods: Longitudinal smooth muscle strips were prepared from the gastric fundi of mice. The contractions of smooth muscle strips were recorded with an isometric force displacement transducer.
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