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Safety and efficacy of a combination of pethidine and levallorphan for pain relief during labor: An observational study.
J Obstet Gynaecol Res
February 2019
Department of Obstetrics/Gynecology, Amagasaki Medical Coop Hospital, Amagasaki, Japan.
Aim: To evaluate the safety, effect on breastfeeding and efficacy of a combination of pethidine and levallorphan (Pethilorfan) for pain relief during labor.
Methods: We compared maternal or neonatal morbidities, suckling difficulties in newborns and breastfeeding rates between 177 women who received 50-200 mg (as pethidine) of Pethilorfan during labor (Pethilorfan group) and 354 women who delivered their infants without analgesic drugs immediately before or after each woman in the Pethilorfan group (control group) from January 1, 2005 to December 31, 2016. We performed univariate and multivariate analyses for comparison between the two groups.
Discrimination of a single dose of morphine followed by naltrexone: substitution of other agonists for morphine and other antagonists for naltrexone in a rat model of acute dependence.
J Pharmacol Exp Ther
March 2003
Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Rats were trained to discriminate 4-h pretreatment with 10 mg/kg morphine and 15-min pretreatment with 0.3 mg/kg naltrexone (morphine-->naltrexone) from pretreatment with saline and 0.3 mg/kg naltrexone (saline-->naltrexone).
View Article and Find Full Text PDFCharacterization of opioid agonist efficacy in a C6 glioma cell line expressing the mu opioid receptor.
J Pharmacol Exp Ther
September 1996
Department of Pharmacology, University of Michigan, Ann Arbor, USA.
In C6 glioma cells stably expressing a homogeneous population of the cloned rat mu opioid receptor, the binding affinities of opioid agonists and subsequent activation of G protein were examined. Opioid receptor number in membranes of these cells was high (10-30 pmol/mg protein [3H]diprenorphine binding sites). Opioids were found to bind to the receptor with high affinity [Tyr-D-Ala-Gly-(Me)Phe-Gly-ol (DAMGO) 0.
View Article and Find Full Text PDFAirway opioid receptors mediate inhibition of cough and reflex bronchoconstriction in guinea pigs.
J Pharmacol Exp Ther
February 1990
Pharmacological Laboratory, AB Draco, Lund, Sweden.
Effects of opioids and opioid antagonists on citric acid-induced cough and reflex bronchoconstriction have been examined in conscious guinea pigs. Airway reflexes produced by inhaled citric acid are mediated by capsaicin sensitive sensory neurons, and we examined particularly the possibility that inhibitory effects of opioids can be exerted locally in the airway. As expected, systemically administered codeine (1-10 mg/kg), meperidine (3-30 mg/kg) and morphine (1-10 mg/kg) dose-dependently inhibited cough and bronchoconstriction.
View Article and Find Full Text PDFEffects of opioids on the ACh-induced contraction of the toad rectus.
Clin Exp Pharmacol Physiol
March 1986
The inhibitory effect of morphine, nalorphine, oxymorphone, naloxone, naltrexone, N-methylnaloxone, levorphanol, levallophan, dextrorphan, dextrallophan, levo-methadone, dextro-methadone, pethidine, leu-enkephalin and U-50 488 on the acetylcholine (ACh)-induced contraction of the toad rectus was investigated. The dose-response curves obtained in the absence and presence of increasing concentrations (0.1-3.
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