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Influence of subclinical hypothyroidism and brain-derived neurotropic factor on telomere length dynamics in type 1 diabetic pregnancies and their newborns.
Sci Rep
January 2025
Department of Obstetrics and Gynecology, University Hospital Centre Zagreb, 10000, Zagreb, Croatia.
Thyroid dysfunctions are common in type 1 diabetes mellitus (T1DM) pregnancies, impacting embryogenesis and fetal neurodevelopment. This study investigates the effects of subclinical hypothyroidism and BDNF (Brain-derived neurotrophic factor) telomere length in T1DM mothers and their newborns. In a recent study, researchers found an inverse relationship between TSH (thyroid-stimulating hormone) levels and telomere length in the cord blood of newborns.
View Article and Find Full Text PDFTrends and epidemiology of children treated in specialized burn centers in the Netherlands between 2009 and 2022.
Eur J Pediatr
January 2025
Alliance of Dutch Burn Care, Burn Center, Red Cross Hospital, PO Box 1074, 1940 EB, Beverwijk, the Netherlands.
Article Synopsis
- The study examines trends and epidemiology of pediatric burns in Dutch burn centers from 2009 to 2022, highlighting the need for effective prevention strategies and resource allocation.
- The analysis revealed a gradual increase in pediatric burn admissions, with a temporary decrease during the COVID-19 pandemic; 77% of patients were overnight admissions.
- Young children (ages 0-3) were the most affected group, and a shift toward shorter hospital stays and increased day admissions was noted, especially during the pandemic.
Association Between COVID-19 Pandemic Phases and the Risk of Maternal Intensive Care Unit Admission: A Retrospective Analysis of 215,363 Victorian Hospital Admissions.
Aust N Z J Obstet Gynaecol
January 2025
Department of Obstetrics, Gynaecology and Newborn Health, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia.
Background: There are no published Australian population-based data on serious COVID-19-associated maternal morbidity before and after widespread vaccination.
Aims: To compare COVID-19 infection rates, intensive care unit (ICU) admissions, and length of stay in hospitalised pregnant patients before and after achieving 70% state-wide maternal COVID-19 vaccination coverage.
Material And Methods: Population-based retrospective cohort study involving all hospital-admitted episodes for pregnant patients over 15-years-old with COVID-19 in Victoria from 1 March 2020 to 31 March 2022.
Total hip arthroplasty preoperative planning for childhood hip disorders' sequelae: Focus on developmental dysplasia of the hip.
World J Orthop
December 2024
Department of Trauma and Orthopaedics, AOSP Terni, Terni 05100, Italy.
Developmental dysplasia of the hip (DDH) poses significant challenges in both childhood and adulthood, affecting up to 10 per 1000 live births in the United Kingdom and United States. While newborn screening aims to detect DDH early, missed diagnoses can lead to severe complications such as hip dysplasia and early onset osteoarthritis in adults. Treatment options range from less invasive procedures like hip-preserving surgery to more extensive interventions such as total hip arthroplasty (THA), depending on the severity of the condition.
View Article and Find Full Text PDFDecreased telomerase activity and shortened telomere length in infants whose mothers have gestational diabetes mellitus and increased severity of telomere shortening in male infants.
Front Endocrinol (Lausanne)
December 2024
Department of Obstetrics and Gynecology, Hefei Maternal and Child Health Hospital, Hefei, China.
Objective: Gestational diabetes mellitus (GDM) is a common complication during pregnancy and increases the risk of metabolic diseases in offspring. We hypothesize that the poor intrauterine environment in pregnant women with GDM may lead to chromosomal DNA damage and telomere damage in umbilical cord blood cells, providing evidence of an association between intrauterine programming and increased long-term metabolic disease risk in offspring.
Methods: We measured telomere length (TL), serum telomerase (TE) activity, and oxidative stress markers in umbilical cord blood mononuclear cells (CBMCs) from pregnant women with GDM (N=200) and healthy controls (Ctrls) (N=200) and analysed the associations of TL with demographic characteristics, biochemical indicators, and blood glucose levels.
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