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NNMT promotes acquired EGFR-TKI resistance by forming EGR1 and lactate-mediated double positive feedback loops in non-small cell lung cancer.
Mol Cancer
March 2025
Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, 211166, China.
Background: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are remarkably effective for treating EGFR-mutant non-small cell lung cancer (NSCLC). However, patients inevitably develop acquired drug resistance, resulting in recurrence or metastasis. It is important to identify novel effective therapeutic targets to reverse acquired TKI resistance.
View Article and Find Full Text PDFPsychometric properties of the Persian version of the ambivalent ageism scale (benevolent and hostile) in the adult population in Iran.
BMC Psychol
March 2025
Faculty of Nursing and Midwifery, Nursing Research Center, Golestan University of Medical Sciences, Gorgan, Iran.
Background: With the growing population of older adults and the prevalence of negative attitudes towards them, the issue of ageism and its health and economic impacts in both benevolent and hostile contexts warrants special attention. It is crucial to examine the attitudes of other age groups towards older adults across different societies. Particularly, the benevolent dimension of ageism, which has been less explored in research, requires more focus.
View Article and Find Full Text PDFExecutive functions in everyday life in children born small for gestational age - a pilot study of pre-term to full-term children 3 years and younger.
BMC Pediatr
March 2025
Faculty of Health and Life Sciences, MEO, Linnaeus University, Kalmar, Region Kalmar County, Sweden.
Background: Children born small for gestational age (SGA) have shown an increased risk of developing cognitive impairment and more difficulties regarding academic performance later in life. However, it is not known whether cognitive impairment can be detected in very young children. This study aimed to investigate whether children born SGA, with a birthweight of ≤ 3 SD, aged 2:6-3:0 years, showed impairments of executive functions in everyday life based on parental ratings, compared to children born appropriate for gestational age (AGA).
View Article and Find Full Text PDFMovimente program: effectiveness and moderators of a cluster-randomized controlled trial on self-reported physical activity among Brazilian adolescents.
BMC Public Health
March 2025
Institute for Physical Activity and Nutrition, Deakin University, 221 Burwood Highway, Burwood, Melbourne, VIC, 3125, Australia.
Background: School-based intervention are needed due to the low levels of physical activity among adolescents.
Objective: To evaluate a school-based intervention's effectiveness and potential sociodemographic moderators on physical activity (PA) among Brazilian adolescents.
Design: The Movimente Program was a cluster randomized controlled trial conducted at six elementary schools in southern Brazil in 2017.
Assessment of the psychometric properties of the Italian version of the revised impact of miscarriage scale (RIMS): a validity and reliability study.
BMC Pregnancy Childbirth
March 2025
CiaoLapo Foundation for Healthy Pregnancy, Stillbirth and Perinatal Loss Support, Via degli Abatoni, 11/11, Prato, 59100, Italy.
Background: Miscarriage is a traumatic life event that involves over forty thousand Italian women every year. Women affected by this loss can have long-term psychological consequences. For this reason, it is paramount to identify women at risk of developing such complications to ensure they receive proper support.
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