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Mitochondrial glutaredoxin Grx5 functions as a central hub for cellular iron-sulfur cluster assembly.
J Biol Chem
March 2025
Department of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ, 07103, USA. Electronic address:
Iron-sulfur (FeS) protein biogenesis in eukaryotes is mediated by two different machineries - one in the mitochondria and another in the cytoplasm. Glutaredoxin 5 (Grx5) is a component of the mitochondrial iron-sulfur cluster (ISC) machinery. Here we define the roles of Grx5 in maintaining overall mitochondrial/cellular FeS protein biogenesis, utilizing mitochondria and cytoplasm isolated from Saccharomyces cerevisiae cells.
View Article and Find Full Text PDFPhosphatidylcholine synthesis and remodeling in brain endothelial cells.
J Lipid Res
March 2025
LIMES Life and Medical Sciences Institute, University of Bonn, Bonn, Germany. Electronic address:
Mammalian cells synthesize hundreds of different variants of their prominent membrane lipid phosphatidylcholine (PC), all differing in the side chain composition. This batch is constantly remodeled by the Lands cycle, a metabolic pathway replacing one chain at the time. Using the alkyne lipid lyso-phosphatidylpropargylcholine (LpPC), a precursor and intermediate in PC synthesis and remodeling, we study both processes in brain endothelial bEND3 cells.
View Article and Find Full Text PDFElucidating the co-metabolism mechanism of 4-chlorophenol and 4-chloroaniline degradation by Rhodococcus through genomics and transcriptomics.
Environ Res
March 2025
College of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao 266580, PR China; State Key Laboratory of Heavy Oil Processing, China University of Petroleum (East China), Qingdao, Shandong 266580, China.
Co-metabolism is an effective strategy for the removal of refractory pollutants during biodegradation. This study reports that Rhodococcus DCB-5 can utilize 4-chlorophenol as a growth substrate to initiate the co-metabolic degradation of 4-chloroaniline. Comprehensive analyses of the genome, transcriptome, enzymes, and intermediate products identified key genes and a putative co-metabolic degradation pathway involved in the degradation process by Rhodococcus.
View Article and Find Full Text PDFInnateness transcriptome gradients characterize mouse T lymphocyte populations.
J Immunol
February 2025
La Jolla Institute for Immunology, La Jolla, CA, United States.
A fundamental dichotomy in lymphocytes separates adaptive T and B lymphocytes, with clonally expressed antigen receptors, from innate lymphocytes, which carry out more rapid responses. Some T cell populations, however, are intermediates between these 2 poles, with the capacity to respond rapidly through T cell receptor activation or by cytokine stimulation. Here, using publicly available datasets, we constructed linear mixed models that not only define a gradient of innate gene expression in common for mouse innate-like T cells, but also are applicable to other mouse T lymphoid populations.
View Article and Find Full Text PDFAn NRF2/β3-Adrenoreceptor Axis Drives a Sustained Antioxidant and Metabolic Rewiring Through the Pentose-Phosphate Pathway to Alleviate Cardiac Stress.
Circulation
March 2025
Institute of Experimental and Clinical Research (IREC), Pharmacology and Therapeutics (FATH), Cliniques Universitaires St. Luc and Université catholique de Louvain, Brussels, Belgium (L.Y.M.M., H.E., D.d.M., R.V., N.F., J.-L.B.).
Background: Cardiac β3-adrenergic receptors (ARs) are upregulated in diseased hearts and mediate antithetic effects to those of β1AR and β2AR. β3AR agonists were recently shown to protect against myocardial remodeling in preclinical studies and to improve systolic function in patients with severe heart failure. However, the underlying mechanisms remain elusive.
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