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Polystyrene microplastics disrupt adrenal steroid synthesis in male mice via mitochondrial dysfunction.
Ecotoxicol Environ Saf
December 2024
Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan 430071, China. Electronic address:
Microplastics have gained significant social attention, as they can enter our bodies through food and drinking water. The adrenal gland is essential for the maintenance of metabolic homeostasis and stress responses. Nevertheless, the effects of microplastics on the steroid synthesis in the adrenal cortex was still unclear.
View Article and Find Full Text PDFEffects of grain intervention on hypothalamic function and the metabolome of blood and milk in dairy cows.
J Anim Sci Biotechnol
June 2024
Laboratory of Gastrointestinal Microbiology, Jiangsu Key Laboratory of Gastrointestinal Nutrition and Animal Health, National Center for International Research On Animal Gut Nutrition, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, 210095, China.
Background: The hypothalamus plays a crucial role in the health and productivity of dairy cows, yet studies on its functionality and its impact on peripheral circulation in these animals are relatively scarce, particularly regarding dietary interventions. Therefore, our study undertook a comprehensive analysis, incorporating both metabolomics and transcriptomics, to explore the effects of a grain-based diet on the functionality of the hypothalamus, as well as on blood and milk in dairy cows.
Results: The hypothalamic metabolome analysis revealed a significant reduction in prostaglandin E (PGE) level as a prominent response to the grain-based diet introduction.
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