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Novel genetic insight for psoriasis: integrative genome-wide analyses in 863 080 individuals and proteome-wide Mendelian randomization.

Brief Bioinform

November 2024

Department of Dermatology, Daping Hospital, Army Medical University, No. 10, Changjiang Branch Road, Yuzhong District, Chongqing 400042, China.

Psoriasis affects a significant proportion of the worldwide population and causes an extremely heavy psychological and physical burden. The existing therapeutic schemes have many deficiencies such as limited efficacies and various side effects. Therefore, novel ways of treating psoriasis are urgently needed.

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Assessing blood metal levels in house sparrows (Passer domesticus) across urban and rural habitats in Meknes.

Environ Sci Pollut Res Int

January 2025

Natural Resources Management and Development Team, Environment and Health Laboratory, Department of Biology, Faculty of Sciences, Moulay Ismaïl University, Zitoune, B.P.11201, Meknes, Morocco.

This study investigates the concentration of heavy metals lead (Pb), cadmium (Cd), and zinc (Zn) in the blood of house sparrows (Passer domesticus) across various urban habitats in Meknes, Morocco. Fifty adult sparrows were captured from five distinct sites, including industrial, high-traffic, and rural areas. Blood samples were specifically analyzed for Pb, Cd, and Zn using Inductively Coupled Plasma Atomic Emission Spectroscopy (ICP-AES).

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A simple and effective method to remove pigments from heterologous secretory proteins expressed in Pichia pastoris.

Adv Biotechnol (Singap)

February 2024

CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200030, China.

Pichia pastoris is a popular yeast host for high-level heterologous expression of proteins on an industrial scale owing to its reliable expression, robust growth, high fermentation density, and easy genetic manipulation and cultivation at a relatively low cost. Of particular interest is its high secretion efficiency for small proteins including insulin, human serum albumin, vaccines, enzymes, and llama-derived heavy-chain only antibodies (nanobodies) for pharmaceutical and research applications. However, a recurring challenge in using P.

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Under current climate change patterns, rapidly changing environments can impose strong selection on traits. Costly traits that require heavy investment and strongly affect fitness may be particularly vulnerable to such changes. Despite organisms experiencing dynamic environments, our knowledge of costly trait response is limited as longitudinal studies across generations are rare.

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This work focused on the biotreatment of wastewater and contaminated soil in a used oil recycling plant located in Bizerte. A continuous stirred tank reactor (CSTR) and a trickling filter (TF) were used to treat stripped and collected wastewater, respectively. The CSTR was started up and stabilized for 90 days.

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