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5α-reductase inhibitors: Evaluation of their potential confounding effect on GC-C-IRMS doping analysis.
Drug Test Anal
November 2021
Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Rome, Italy.
5α-reductase inhibitors (5-ARIs) are considered by the World Anti-doping Agency as potential confounding factors in evaluating the athlete steroid profile, since they may interfere with the urinary excretion of several diagnostic compounds. We herein investigated 5α-reductase inhibitors from a different perspective, by verifying their influence on the carbon isotopic composition of 5α- and 5β-reduced testosterone and nandrolone metabolites. The GC-C-IRMS analysis was performed on a set of urine samples collected from three male Caucasian volunteers after the acute and chronic administration of finasteride in combination with the intake of 19-norandrostenedione, a nandrolone precursor.
View Article and Find Full Text PDFHuman efflux transport of testosterone, epitestosterone and other androgen glucuronides.
J Steroid Biochem Mol Biol
March 2020
Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland.
Several drug-metabolizing enzymes are known to control androgen homeostasis in humans. UDP-glucuronosyltransferases convert androgens to glucuronide conjugates in the liver and intestine, which enables subsequent elimination of these conjugated androgens via urine. The most important androgen is testosterone, while others are the testosterone metabolites androsterone and etiocholanolone, and the testosterone precursor dehydroepiandrosterone.
View Article and Find Full Text PDFIsotope ratio mass spectrometry in antidoping analysis: The use of endogenous reference compounds.
Rapid Commun Mass Spectrom
March 2019
Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Largo Giulio Onesti 1, 00197, Rome, Italy.
Rationale: Isotope ratio mass spectrometry (IRMS) is an analytical technique required by the World Antidoping Agency (WADA) before releasing of an adverse finding for the abuse of pseudoendogenous steroids (i.e. testosterone).
View Article and Find Full Text PDFSerum androgen profile and physical performance in women Olympic athletes.
Br J Sports Med
September 2017
Department of Women's and Children's Health, Division of Obstetrics and Gynecology, Karolinska Institutet, Stockholm, Sweden.
Background: The role of endogenous androgens for body composition and physical performance in women athletes is still not elucidated.
Aim: To examine the serum androgen profile in relation to body composition and physical performance in women Olympic athletes and to compare endocrine variables and body composition to controls.
Study Design: Cross-sectional study, conducted between 2011 and 2015 at the Women's Health Research Unit, Karolinska University Hospital, Stockholm.
Impact of progesterone administration on doping test of endogenous steroids.
Anal Bioanal Chem
September 2014
National Anti-Doping Laboratory, China Anti-Doping Agency, 100029, Beijing, China,
Progesterone (PROG) is a naturally occurring progestagen, which has been used to prevent preterm birth, control persistent anovulatory bleeding, and treat premenstrual syndrome in clinical practices. Studies on the metabolism of PROG have demonstrated that PROG is the precursor of other steroids such as 5β-pregnane-3α,20α-diol (PD), testosterone (T), and 17-hydroxyprogesterone. PD is the most commonly used endogenous reference compound (ERC) in the isotope ratio mass spectrometry (IRMS) analysis for doping control.
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