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CD4-Derived Double-Negative T Cells Ameliorate Alzheimer's Disease-Like Phenotypes in the 5×FAD Mouse Model.
CNS Neurosci Ther
January 2025
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China.
Background: Alzheimer's disease (AD) is a debilitating neurodegenerative disorder that is difficult to predict and is typically diagnosed only after symptoms manifest. Recently, CD4 T cell-derived double-negative T (DNT) cells have shown strong immuno-regulatory properties in both in vitro and in vivo neuronal inflammation studies. However, the effectiveness of DNT cells in treating on AD are not yet fully understood.
View Article and Find Full Text PDFProgesterone Regulates Gut Microbiota Mediating Bone Marrow MSCs Injury in ITP Patients during Pregnancy.
J Thromb Haemost
January 2025
Peking University People's Hospital, Peking University Institute of Hematology, Beijing, China; National Clinical Research Center for Hematologic Disease, Beijing, China; Collaborative Innovation Center of Hematology, Peking University, Beijing, China; Clinical Research Center for Hematologic Disease, Beijing, China. Electronic address:
Background: Immune thrombocytopenia during pregnancy (PITP) is the most common cause of platelet reduction in early and mid-pregnancy. However, the pathogenesis of PITP is still unclear.
Objectives: To determine the characteristics of bone marrow mesenchymal stem cells (BM-MSCs) in PITP patients and to explore the associations between metabolites, the gut microbiota, and BM-MSCs in PITP.
Gelatin methacryloyl hydrogel encapsulating molybdenum-inspired macrophage-derived exosomes accelerates wound healing via immune regulation and angiogenesis.
Int J Biol Macromol
December 2024
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China; Department of Periodontology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China. Electronic address:
Clinically, abnormal or delayed wound healing leads to functional disorders and disfiguring scars. A well-vascularized environment and an anti-inflammatory immune state are crucial during the healing process. Molybdenum (Mo) is an essential element for the human body in modulating metabolism, immune function and tissue repair.
View Article and Find Full Text PDFHuman mesenchymal stem/stromal cell based-therapy in diabetes mellitus: experimental and clinical perspectives.
Stem Cell Res Ther
October 2024
Human Medical Molecular Genetics Department, Human Genetics and Genome Research Institute, National Research Centre (NRC), Cairo, 12622, Egypt.
Article Synopsis
- - Diabetes mellitus (DM) is a major global health issue, and current treatments often do not effectively prevent long-term complications, prompting interest in the use of mesenchymal stem/stromal cells (MSCs) for treatment.
- - MSCs have regenerative properties and can improve diabetes outcomes by enhancing insulin production, reducing insulin resistance, and protecting insulin-producing beta cells, with evidence from animal studies and clinical trials showing positive effects.
- - The review also highlights different strategies to optimize MSC treatment for diabetes, discusses the potential of MSC-derived extracellular vesicles, and addresses challenges like sourcing MSCs and the need for larger clinical trials to better understand their safety and efficacy.
A coumarin derivative C7 exhibits antiviral activity against WSSV by reducing phosphatidylcholine content in shrimp.
Fish Shellfish Immunol
November 2024
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, School of Marine Sciences, Ningbo University, Ningbo, 315211, China; Key Laboratory of Aquacultural Biotechnology, Ministry of Education, School of Marine Sciences, Ningbo University, Ningbo, Zhejiang, 315211, China; Laboratory of Biochemistry and Molecular Biology, School of Marine Sciences, Meishan Campus, Ningbo University, Ningbo, 315832, China. Electronic address:
The white spot syndrome virus (WSSV) causes white spot disease (WSD), a severe condition in crustacean aquaculture, leading to significant economic losses. Our previous study demonstrated that C7 is an effective therapeutic agent against WSSV infection in aquaculture. It specifically blocked viral horizontal transmission and reduced shrimp mortality in a dose- and time-dependent manner.
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