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m6A modified pre-miR-503-5p contributes to myogenic differentiation through the activation of mTOR pathway.
Int J Biol Macromol
January 2025
Sanya Research Institute of Nanjing Agricultural University, Nanjing Agricultural University, Sanya 572025, China; Jiangsu Livestock Embryo Engineering Laboratory, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:
The post-transcriptional regulation of epigenetic modification is a hot topic in skeletal muscle development research. Both m6A modifications and miRNAs have been well-established as crucial regulators in skeletal muscle development. However, the interacting regulatory mechanisms between m6A modifications and miRNAs in skeletal muscle development remain unclear.
View Article and Find Full Text PDFExploring Gene Expression and Alternative Splicing in Duck Embryonic Myoblasts via Full-Length Transcriptome Sequencing.
Vet Sci
November 2024
College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China.
Article Synopsis
- The duck industry plays a crucial role in providing high-quality protein, necessitating research on duck skeletal muscle to improve meat and egg production.
- Utilizing Oxford Nanopore Technologies (ONT) sequencing, the study analyzed myoblasts from duck embryos' leg muscles, uncovering 5797 novel transcripts and significant gene expression changes related to muscle development.
- Key findings included 3653 differentially expressed genes and a protein-protein interaction network identifying critical regulators for muscle cell proliferation and differentiation, highlighting the potential for improved breeding strategies in duck production.
Mll4 in skeletal muscle fibers maintains muscle stem cells.
Skelet Muscle
December 2024
School of Biological Sciences, Seoul National University, Seoul, 08826, Republic of Korea.
Background: Muscle stem cells (MuSCs) undergo numerous state transitions throughout life, which are critical for supporting normal muscle growth and regeneration. Epigenetic modifications in skeletal muscle play a significant role in influencing the niche and cellular states of MuSCs. Mixed-lineage leukemia 4 (Mll4) is a histone methyltransferase critical for activating the transcription of various target genes and is highly expressed in skeletal muscle.
View Article and Find Full Text PDFLow-molecular-weight polyphenol promotes cell sensitivity to cisplatin and alleviates cancer-related muscle atrophy via NF-κB suppression in oral squamous cell carcinoma.
J Oral Biosci
December 2024
Department of Life Sciences, National Cheng Kung University, Tainan, Taiwan R.O.C; Marine Biology and Cetacean Research Center, National Cheng Kung University, Tainan, Taiwan R.O.C. Electronic address:
Objective: Drug resistance and subsequent adverse effects, such as cancer cachexia, limit the clinical use of cisplatin. Oligonol® (Olg), a low-molecular-weight polyphenol, exhibits NF-κB inhibitory properties. NF-κB activation has been implicated in cisplatin resistance of cancer cells and skeletal muscle wasting.
View Article and Find Full Text PDFVisualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies.
Elife
December 2024
Translational Cardiology and Functional Genomics, Max Delbrück Center for Molecular Medicine, Berlin, Germany.
The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse. The logistics underlying myofilament assembly and disassembly have started to emerge with the possibility to follow labeled sarcomere components. Here, we generated the mCherry knock-in at titin's Z-disk to study skeletal muscle development and remodeling.
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