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MarR family regulator LcbR2 activates lincomycin biosynthesis in multiple ways.
Int J Biol Macromol
January 2025
Department of Applied Biology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, China.
Lincomycin, produced by the actinomycete Streptomyces lincolnensis, is highly effective against Gram-positive bacteria and protozoans, making it widely used in clinical settings. This study identified LcbR2, a MarR family transcriptional regulator, as an activator of lincomycin biosynthesis. Knocking out the lcbR2 gene reduced lincomycin production by 63.
View Article and Find Full Text PDFApproaches for the preparation and evaluation of hydrophilic polyethylene and polyethylene terephthalate microplastic particles suited for toxicological effect studies.
Anal Bioanal Chem
January 2025
European Commission, Joint Research Centre (JRC), Geel, Belgium.
When performing effect studies to investigate the impact of microplastic (MP) on cell lines, algae, or daphnia, it is advantageous if such experiments can be performed without the use of surfactants. The need for surfactants arises from the fact that finely milled pristine MP particles generally are hydrophobic. Methods for the preparation of larger amounts of hydrophilic and hence artificially aged MP particles and approaches for their characterization are of high importance.
View Article and Find Full Text PDFGenetic predisposition to Behcet's disease mediated by a IL10RA enhancer polymorphism.
Heliyon
January 2025
The First Affiliated Hospital of Chongqing Medical University, Chongqing Branch (Municipality Division) of National Clinical Research Center for Ocular Diseases, Chongqing, PR China.
Background: Several studies suggested the genetic association between IL10RA variants and susceptibility to Behcet's disease (BD). However, the precise mechanism of the association is still unknown. The purpose of this study was to investigate the mechanism underlying the genetic associations between IL10RA polymorphisms and the risk of BD.
View Article and Find Full Text PDFOptimization, validation, and greenness assessment of a capillary zone electrophoresis method for analysis of inorganic and organic anions in human milk oligosaccharides.
Talanta
January 2025
DSM-Firmenich, Kogle Allé 4, 2970, Hørsholm, Denmark.
The development and validation of an accurate, selective, and eco-friendly capillary zone electrophoretic detection (CZE) method has been presented for concurrent measurement of inorganic and organic anions including chloride, sulfate, formic acid, citric acid, acetic acid, phosphate, and glutamic acid in Human Milk Oligosaccharides (HMOs) for the first time. An electrolyte composed of an aqueous solution of benzoic acid, 16.38 mM; l-histidine, 24.
View Article and Find Full Text PDFNAA enhances armillaria gallica growth by modulating nitrogen metabolism through AgZFP48.
Int J Biol Macromol
January 2025
Faculty of Life Science and Technology, Kunming University of Science and Technology, Chenggong, 650500 Kunming, China. Electronic address:
Armillaria gallica (A. gallica) is a fungus with both medicinal and edible properties. Previous transcriptome analysis has identified the C2H2-type zinc finger transcription factor as a candidate gene involved in the NAA-induced growth promotion of A.
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