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Identification of key gene signatures for predicting chemo-immunotherapy efficacy in extensive-stage small-cell lung cancer using machine learning.
Lung Cancer
January 2025
Internal Medicine III, Wakayama Medical University, Wakayama, Japan.
Objectives: The lack of definitive biomarkers presents a significant challenge for chemo-immunotherapy in extensive-stage small-cell lung cancer (ES-SCLC). We aimed to identify key genes associated with chemo-immunotherapy efficacy in ES-SCLC through comprehensive gene expression analysis using machine learning (ML).
Methods: A prospective multicenter cohort of patients with ES-SCLC who received first-line chemo-immunotherapy was analyzed.
Prevalence and factors associated with potential clinically significant drug-drug interactions in patients with cardiovascular diseases at hospital admission.
Acta Pharm
December 2024
Department of Clinical Pharmacy, University Hospital Dubrava, 10000 Zagreb Croatia.
Cardiovascular diseases (CVDs) are the leading cause of mortality and morbidity globally. It is estimated that 17.9 million people died from CVDs in 2019, which represents 32 % of all deaths worldwide.
View Article and Find Full Text PDFEfficacy of Unsupervised YouTube Dance Exercise for Patients With Hypertension: Randomized Controlled Trial.
JMIR Cardio
January 2025
Department of General Medicine, Faculty of Medicine, Juntendo University, Tokyo, Japan.
Background: High blood pressure (BP) is linked to unhealthy lifestyles, and its treatment includes medications and exercise therapy. Many previous studies have evaluated the effects of exercise on BP improvement; however, exercise requires securing a location, time, and staff, which can be challenging in clinical settings. The antihypertensive effects of dance exercise for patients with hypertension have already been verified, and it has been found that adherence and dropout rates are better compared to other forms of exercise.
View Article and Find Full Text PDFInvestigation of the Content Offered to the Public Regarding Noise Pollution in Online News.
Noise Health
January 2025
Department of Public Health, William Paterson University, Wayne, New Jersey, USA.
Background/objectives: Noise remains an under-discussed type of environmental pollutant, which exerts a wide range of adverse health effects, both auditory and non-auditory. Ensuring that the public has ready access to useful health information online about noise exposure is important. In this regard, evaluating the content of public news articles regarding noise pollution is vital.
View Article and Find Full Text PDFCorrelation between Occupational Noise Exposure and Renal Dysfunction in Male Workers.
Noise Health
January 2025
Department of Pain, Qingdao Municipal Hospital, Qingdao, China.
Objective: This study aimed to explore the relationship between occupational noise exposure and renal dysfunction in male workers.
Methods: A total of 160 male workers (the number of people who met the inclusion criteria) who underwent health examinations in Qingdao Municipal Hospital from January 2023 to December 2023 were grouped into a noise group (80 cases) and a control group (80 cases) based on whether they engaged in noise work. We compared the differences in creatinine (CREA), cystatin C (CysC) and blood urea nitrogen (BUN) levels between the two groups.
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