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[Hydrophilic implant surfaces – a clinical and scientific update (in German)].

Swiss Dent J

January 2018

Klink für Mund-, Kiefer- und Gesichtschirurgie – Klinik für Oralchirurgie Zentrum für Zahnmedizin der Universität Zürich, Universitätsspital Zürich

The modification of the implant surface influences implant osseointegration. A physico-chemical means to modify implant surfaces is the creation of hydrophilic surfaces. The aim is an accelerated osseointegration for earlier implant loading and possibly the increase of bone quantity and quality.

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The technical success rate of endovascular interventions in order to improve perfusion in peripheral arterial disease in the lower extremities has been markedly improved in the last decade due to clinical application of new recanalization techniques like application of hydrophil-coated guide wires, implantation of stents or stent grafts. If the-even long-segment-obstruction can be recanalized, the interventional radiologist is able to open the arterial vessel sufficiently. The excellent immediate results are limited in the long term by recurrent stenoses, which appear in different rates according to the vascular region.

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The bioequivalence of oral dosage forms of oxprenolol was assessed in a triple crossover study on two groups of 12 volunteers each. Single 160 mg doses of oxprenolol hydrochloride were given after an overnight fast of either oxprenolol sustained-release tablets in a megaloporous system, a hydrophil matrix and Slow-Trasicor (Ciba-Geigy) in the first group, or floating slow-release tablets administered with food or in absence of food, and rapid release Oxprenolol (Terapia, Cluj-Napoca) tablets, in the second group. Serum oxprenolol concentrations were measured by a gas chromatographic method.

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