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Fluoride Induces Toxic Effects on the A549 Pulmonary Cell Line at Non-cytotoxic Concentrations.
Biol Trace Elem Res
January 2025
Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, AvInstituto Politécnico Nacional 2508, Col San Pedro ZacatencoCDMX, C.P. 07360, Mexico City, Mexico.
Fluoride is emitted into the air not only through gas emissions but also from volcanic ash, leading to contact via inhalation. Therefore, the objective of the present study was to evaluate the cellular and biochemical responses in the A549 cell line after exposure to NaF (sodium fluoride) concentrations lower than those previously used in other studies to determine the impact on the lung epithelium. A549 cells were exposed to different concentrations (0.
View Article and Find Full Text PDFA preclinical study on effect of betanin on sodium fluoride induced hepatorenal toxicity in wistar rats.
J Complement Integr Med
January 2025
Department of Basic Medical Sciences, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India.
Article Synopsis
- Excessive fluoride exposure can cause oxidative stress and damage metabolic organs, leading to toxicity in the liver and kidneys.
- A study was conducted on Wistar rats divided into four groups, with some receiving sodium fluoride alone and others receiving fluoride with different doses of betanin from beetroot for 90 days.
- Results showed that betanin treatment reduced markers of liver and kidney damage and improved oxidative stress indicators, suggesting it could potentially protect against fluoride-induced organ toxicity.
Li-Based Nanoprobes with Boosted Photoluminescence for Temperature Visualization in NIR Imaging-Guided Drug Release.
Nano Lett
January 2025
Key Laboratory of Physics and Technology for Advanced Batteries, College of Physics, Jilin University, Changchun 130012, China.
Lanthanide-doped fluoride nanocrystals have emerged as promising tools in biomedicine, yet their applications are still limited by their low luminescence efficiency. Herein, we developed highly efficient lithium-based core-shell-shell (CSS) nanoprobes (NPs) featuring a rhombic active domain and a spherical inert protective shell. By introducing Yb as an energy transfer bridge and optimizing the CSS design, a remarkable 1643-fold enhancement in visible emission and a 33-fold increase in NIR emission are achieved compared to original nanoparticles.
View Article and Find Full Text PDFOral Health-Related Quality of Life of Children Following Different Treatment Regimens of Silver Diammine Fluoride.
J Dent Child (Chic)
September 2024
Department of Oral Biology, Dr. Gerald Niznick College of Dentistry, Winnipeg, Manitoba, Canada.
To investigate the oral health-related quality of life (OHRQoL) of young children in a randomized clinical trial (RCT) of silver diammine fluoride (SDF) and five percent sodium fluoride varnish (NaFV) to manage early childhood caries (ECC). Children younger than 72 months of age with active dentinal caries lesions (ICDAS 5 or 6) in primary teeth received two applications of 38 percent SDF and five percent NaFV as part of an RCT testing three different frequency regimes (one, four, and six months apart). The Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire was completed at three study visits.
View Article and Find Full Text PDFMitigation of sodium fluoride-induced growth inhibition, immunosuppression, hepatorenal damage, and dysregulation of oxidative stress, apoptosis, and inflammation-related genes by dietary artichoke (Cynara scolymus) leaf extract in Oreochromis niloticus.
Comp Biochem Physiol B Biochem Mol Biol
December 2024
Department of Forensic Medicine & Toxicology, College of Veterinary Medicine, University of Sadat City, Sadat city, Egypt.
This study evaluated the efficacy of integrating artichoke (Cynara scolymus) leaf extract (CSLE) into the Nile tilapia (Oreochromis niloticus) diet to mitigate fluoride (FLR) adverse effects on growth, immune components, renal and hepatic function, and the regulation of oxidative stress, inflammation, and apoptosis-related genes. A 60-day feeding experiment was conducted with 240 O. niloticus fish separated into four groups as follows: a control group (CON) fed on a basic diet, a CSLE group receiving 300 mg CSLE/kg via the diet, a FLR group exposed to 6.
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