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Vitamin A, C and E levels in patients with Non-Alcoholic Fatty Liver Disease: An Indian Cohort Study.
Mymensingh Med J
October 2024
Dr Sukumar Mondithoka, Assistant Professor, Department of Medicine, AIIMS Bhopal, India; E-mail:
Article Synopsis
- - The study compared levels of vitamins A, C, and E in 50 patients with Non-Alcoholic Fatty Liver Disease (NAFLD) and 50 healthy controls, measuring vitamin levels alongside parameters like bone mineral density, fat storage, insulin resistance, and inflammation.
- - Results showed no significant deficiencies in vitamins A or C; however, vitamin E was notably higher in the NAFLD group, with only one deficiency case, contrasting with other research findings.
- - No significant correlations emerged between vitamin levels and the other parameters measured, indicating a need for more research to clarify the relationships among these factors in the context of NAFLD, especially within the Asian Indian population.
Ascorbate insufficiency disrupts glutamatergic signaling and alters electroencephalogram phenotypes in a mouse model of Alzheimer's disease.
Neurobiol Dis
September 2024
Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, United States; Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States. Electronic address:
Clinical studies have reported that increased epileptiform and subclinical epileptiform activity can be detected in many patients with an Alzheimer's disease (AD) diagnosis using electroencephalogram (EEG) and this may correlate with poorer cognition. Ascorbate may have a specific role as a neuromodulator in AD as it is released concomitantly with glutamate reuptake following excitatory neurotransmission. Insufficiency may therefore result in an exacerbated excitatory/inhibitory imbalance in neuronal signaling.
View Article and Find Full Text PDFStrategic administration of antioxidant multiminerals and vitamins to transitional buffaloes augments antioxidant and udder defense mechanisms in early lactation.
Res Vet Sci
June 2024
Division of Medicine, ICAR-Indian Veterinary Research Institute, Izatnagar 243 122, Uttar Pradesh, India.
The aim of the study was to examine the effects of repeated administrations of antioxidant multiminerals and vitamins in transition buffaloes on udder defense mechanism, antioxidant activity and occurrence of intramammary infection (IMI) in early lactation period. Forty clinically healthy pregnant buffaloes were enrolled 45 days before expected date of calving and randomly allocated into five different supplementation groups (n = 8): only basal ration (control), vitamin E and selenium (VES), multiminerals (MM), ascorbic acid (AA) and chromium (Cr) picolinate in basal diet. The udder defense mechanism was monitored by measuring phagocytic activity (PA), myeloperoxidase (MPO) and nitric oxide (NO) productions in milk leukocytes, antioxidant activity was evaluated by measuring total antioxidant capacity (TAC) in plasma and occurrence of IMI was assessed by milk cytology, bacterial count in milk and visible clinical signs of udder until day 28 post-calving.
View Article and Find Full Text PDFAssociation between dietary vitamin C and abdominal aortic calcification among the US adults.
Nutr J
November 2023
National Clinical Research Center for Chinese Medicine Cardiology, Xiyuan Hospital, Academy of Chinese Medical Sciences, Beijing, China.
Background: Cardiovascular disease (CVD) is the leading cause of mortality, and vascular calcification has been highly correlated with CVD events. Abdominal aortic calcification (AAC) has been shown to predict subclinical CVD and incident CVD events. However, the relationship between vitamin C and abdominal aortic calcification remains unclear.
View Article and Find Full Text PDFThyrotropin inhibits osteogenic differentiation of human periodontal ligament stem cells.
J Periodontal Res
June 2023
Department of General Surgery (Thyroid Surgery), the Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China.
Background And Objective: Periodontal ligament stem cells (PDLSCs) are derived from the periodontal ligament and have the characteristics of pluripotent differentiation, including osteogenesis, and are one of the important seed cells in oral tissue engineering. Thyrotropin (TSH) has been shown to regulate bone metabolism independently of thyroid hormone, including the fate of osteoblasts and osteoclasts, but whether it affects osteogenic differentiation of PDLSCs is unknown.
Materials And Methods: PDLSCs were isolated and cultured from human periodontal ligament and grown in osteogenic medium (containing sodium β-glycerophosphate, ascorbic acid, and dexamethasone).
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