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Vaccination status of patients with primary immunodeficiencies in Germany-a multicentric epidemiologic analysis.
Z Rheumatol
February 2025
Institute for Hygiene and Microbiology, University of Würzburg, Josef-Schneider-Straße 2/E1, 97080, Würzburg, Germany.
Background: Vaccinations represent an easily accessible, safe, and important method for preventing infections. Patients with primary immunodeficiencies (PID) are more susceptible to infections and should receive an extended spectrum of immunizations in many countries.
Methods: Between January 2019 and May 2020, vaccination certificates of 70 patients with PID from the regions of Würzburg and Hanover in Germany were evaluated.
Global Case Fatality of Bacterial Meningitis During an 80-Year Period: A Systematic Review and Meta-Analysis.
JAMA Netw Open
August 2024
Department of Neurology, Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands.
Importance: The impact of vaccination, antibiotics, and anti-inflammatory treatment on pathogen distribution and outcome of bacterial meningitis over the past century is uncertain.
Objective: To describe worldwide pathogen distribution and case fatality ratios of community-acquired bacterial meningitis.
Data Sources: Google Scholar and MEDLINE were searched in January 2022 using the search terms bacterial meningitis and mortality.
High-resolution genomics identifies pneumococcal diversity and persistence of vaccine types in children with community-acquired pneumonia in the UK and Ireland.
BMC Microbiol
April 2024
Laboratory of Medical Microbiology, Vaccine & Infectious Disease Institute, Universiteit Antwerpen, Antwerp, Belgium.
Article Synopsis
- Streptococcus pneumoniae is a key cause of pneumonia in children, and a study (CAP-IT trial) examined antibiotic treatment effects on serotype prevalence and resistance, finding no significant differences based on dosage or duration of amoxicillin.
- In-depth genomic analysis of 390 pneumococcal isolates revealed that serotypes 15B/C, 11A, 15A, and 23B1 were the most common, with varying levels of resistance to penicillin and amoxicillin, but overall low resistance rates.
- The findings suggest that current amoxicillin treatment does not influence serotype prevalence, indicating a need for vaccines covering a broader range of pneumococcal serotypes.
Nasopharyngeal carriage of Streptococcus pneumoniae among children <5 years of age in Indonesia prior to pneumococcal conjugate vaccine introduction.
PLoS One
January 2024
National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, United States of America.
Pneumococcal conjugate vaccines (PCVs) prevent nasopharyngeal colonization with vaccine serotypes of Streptococcus pneumoniae, leading to reduced transmission of pneumococci and stronger population-level impact of PCVs. In 2017 we conducted a cross-sectional pneumococcal carriage study in Indonesia among children aged <5 years before 13-valent PCV (PCV13) introduction. Nasopharyngeal swabs were collected during visits to community integrated health service posts at one peri-urban and one rural study site.
View Article and Find Full Text PDFFusion of PspA to detoxified pneumolysin enhances pneumococcal vaccine coverage.
PLoS One
December 2023
Laboratório de Microbiologia Molecular e Clínica, Universidade São Francisco, Bragança Paulista, Brazil.
Despite the implementation of conjugate vaccines in several countries, S. pneumoniae continues to pose a great burden worldwide, causing around 1 million annual deaths. Pneumococcal proteins have long been investigated as serotype-independent vaccines against this pathogen, with promising results.
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