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ACG Clinical Guideline: Diagnosis and Management of Gastric Premalignant Conditions.
Am J Gastroenterol
March 2025
Division of Gastroenterology, University of California, San Diego, La Jolla, California, USA.
Gastric premalignant conditions (GPMC) are common and include atrophic gastritis, gastric intestinal metaplasia, dysplasia, and certain gastric epithelial polyps. GPMC have an increased risk of progression to gastric adenocarcinoma. Gastric cancer (GC) in the United States represents an important cancer disparity because incidence rates are 2- to 13-fold greater in non-White individuals, particularly early-generation immigrants from regions of high GC incidence.
View Article and Find Full Text PDFNovel Controlled Metabolic Accelerator for Obesity-Related HFpEF: The HuMAIN-HFpEF Randomized Clinical Trial.
JAMA Cardiol
March 2025
Department of Cardiovascular Medicine and Section on Geriatrics and Gerontology, Wake Forest University School of Medicine, Winston-Salem, North Carolina.
Importance: Excess body fat plays a pivotal role in the pathogenesis of heart failure with preserved ejection fraction (HFpEF). HU6 is a novel, controlled metabolic accelerator that enhances mitochondrial uncoupling resulting in increased metabolism and fat-specific weight loss.
Objective: To assess efficacy and safety of HU6 in reducing body weight, improving peak volume of oxygen consumption (VO2) and body composition among patients with obesity-related HFpEF.
Anger De-escalation: A Standardized Patient Workshop for Third- and Fourth-Year Medical Students.
MedEdPORTAL
March 2025
Associate Professor, Department of Internal Medicine and Office of Medical Education, University of Kentucky College of Medicine and Lexington Veterans Affairs Health Care.
Introduction: During clinical training, medical students frequently encounter angry patients and loved ones but feel inadequately prepared to de-escalate these encounters. This unpreparedness might contribute to feelings of shame and anger among medical students and burnout among practicing physicians. Challenging patient scenarios abound in the standardized patient (SP) literature, but no published didactic tool exists focusing exclusively on identification and nonpharmaceutical management of patient anger with a target audience of senior medical students.
View Article and Find Full Text PDFProceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications.
Front Hum Neurosci
February 2025
Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, FL, United States.
The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology.
View Article and Find Full Text PDFPhosphorylation of an RNA-Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging.
Aging Cell
March 2025
Neurophysiology and Metabolism Research Group, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Korea.
The metazoan lifespan is determined in part by a complex signaling network that regulates energy metabolism and stress responses. Key signaling hubs in this network include insulin/IGF-1, AMPK, mTOR, and sirtuins. The Hippo/Mammalian Ste20-like Kinase1 (MST1) pathway has been reported to maintain lifespan in Caenorhabditis elegans, but its role has not been studied in higher metazoans.
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