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Motion-Compensated Multishot Pancreatic Diffusion-Weighted Imaging With Deep Learning-Based Denoising.

Invest Radiol

January 2025

From the Department of Radiology, Stanford University, Stanford, CA (K.W., M.J.M., A.M.L., A.B.S., A.J.H., D.B.E., R.L.B.); Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA (K.W.); GE HealthCare, Houston, TX (X.W.); GE HealthCare, Boston, MA (A.G.); and GE HealthCare, Menlo Park, CA (P.L.).

Objectives: Pancreatic diffusion-weighted imaging (DWI) has numerous clinical applications, but conventional single-shot methods suffer from off resonance-induced artifacts like distortion and blurring while cardiovascular motion-induced phase inconsistency leads to quantitative errors and signal loss, limiting its utility. Multishot DWI (msDWI) offers reduced image distortion and blurring relative to single-shot methods but increases sensitivity to motion artifacts. Motion-compensated diffusion-encoding gradients (MCGs) reduce motion artifacts and could improve motion robustness of msDWI but come with the cost of extended echo time, further reducing signal.

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Facial reconstruction, a crucial method in forensic identification, finds particular significance in cases where conventional means of identification are unavailable. This study addresses a significant gap in the field of forensic facial reconstruction focusing on facial soft tissue thickness (FSTT) and facial reconstruction techniques specifically tailored to the Thai population. By developing and implementing the 3D (three-dimensional) facial reconstruction program and compiling an extensive dataset of FSTT, this research makes substantial progress in advancing forensic facial reconstruction methodologies employing the combination Manchester Method, 3D skull images obtained through cone beam computed tomography (CBCT) scans were reconstructed using Autodesk Maya software.

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Background: Children born with cleft palate ± lip (CP ± L) are at risk of speech sound disorder (SSD). Up to 40% continue to have SSD at age 5-6 years. These difficulties are typically described as articulatory in nature and often include cleft speech characteristics (CSC) hypothesized to result from structural differences.

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CohortDiagnostics: Phenotype evaluation across a network of observational data sources using population-level characterization.

PLoS One

January 2025

Observational Health Data Analytics, Janssen Research and Development, LLC, Titusville, NJ, United States of America.

Objective: This paper introduces a novel framework for evaluating phenotype algorithms (PAs) using the open-source tool, Cohort Diagnostics.

Materials And Methods: The method is based on several diagnostic criteria to evaluate a patient cohort returned by a PA. Diagnostics include estimates of incidence rate, index date entry code breakdown, and prevalence of all observed clinical events prior to, on, and after index date.

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Objectives: We applied three electronic triggers to study frequency and contributory factors of missed opportunities for improving diagnosis (MOIDs) in pediatric emergency departments (EDs): return visits within 10 days resulting in admission (Trigger 1), care escalation within 24 h of ED presentation (Trigger 2), and death within 24 h of ED visit (Trigger 3).

Methods: We created an electronic query and reporting template for the triggers and applied them to electronic health record systems of five pediatric EDs for visits from 2019. Clinician reviewers manually screened identified charts and initially categorized them as "unlikely for MOIDs" or "unable to rule out MOIDs" without a detailed chart review.

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