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Inhibiting NLRP3 enhances cellular autophagy induced by outer membrane vesicles from .
Microbiol Spectr
January 2025
Department of Laboratory Medicine, Affiliated Hospital of Nantong University, Nantong, China.
The bacterium is able to invade lung epithelial cells and survive intracellularly. During this process, it secretes outer membrane vesicles (OMVs), however, it is currently unclear how OMVs from (PA-OMVs) affect lung epithelial cells and their impact on oxidative stress, autophagy, and other physiological activities of lung epithelial cells. In this study, we found that PA-OMVs activated oxidative stress and autophagy in cells.
View Article and Find Full Text PDFSodium butyrate activates the extrinsic and intrinsic apoptotic processes in murine cementoblasts.
J Dent Sci
January 2025
School of Dentistry, Chung Shan Medical University, Taichung, Taiwan.
Background: : The metabolic by-product butyric acid of Gram-negative anaerobic bacteria can invoke pathological effects on periodontal cells resulting in inflammation and further destruction of periodontium. However, limited researches on the effects of butyric acid on cementoblasts were reported. Therefore, this study aimed to investigate the type of cell death in murine cementoblast (OCCM.
View Article and Find Full Text PDFTranscription enhanced associate domain factor 1 (TEAD1) predicts liver regeneration outcome of ALPPS-treated patients.
HPB (Oxford)
December 2024
Institute for Clinical Research (IKF), Semmelweis University, Campus Hamburg, Germany; Division of HPB Surgery, Department of Surgery, Asklepios Hospital Barmbek, Hamburg, Germany. Electronic address:
Background: The two-stage surgical technique of associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) enables extensive liver resection and promotes future liver remnant regeneration (FLR), in part by inhibiting the Hippo signalling pathway. Its main effector, Yes-associated protein (YAP), has low intrinsic transcriptional activity and requires the transcription enhanced associated domain factor (TEAD) family members as cofactors for target gene transcription. We evaluated the intracellular localization and expression of TEAD1-4, hypothesized to regulate the activity of YAP and, consequently, liver regeneration.
View Article and Find Full Text PDFThe "magic" of looking at that score: A multilevel investigation of therapist review of client symptom measures and client clinical outcome.
J Couns Psychol
January 2025
Marriage and Family Therapy Program, Sentio University.
Randomized controlled trials have shown that using client feedback obtained from routine outcome monitoring can lead to better clinical outcomes in psychotherapy. However, existing randomized controlled trial studies did not address the between-person and within-person effects of routine outcome monitoring simultaneously. To fill this critical gap, this study conducted a multilevel analysis to explore the effect of therapist utilization of client symptom outcome data in a naturalistic practice setting.
View Article and Find Full Text PDFBreaking down silos and echo chambers: Adolescence through an interdisciplinary lens.
J Res Adolesc
March 2025
Department of Health Policy and Department of Human and Organizational Development, Vanderbilt University, Nashville, Tennessee, USA.
Research on adolescence occurs across a variety of disciplines, including education, psychology, sociology, public health, biology, and medicine, among other fields, each with its own definition of the most pressing problems, levels of analysis, and proposed solutions. There is widespread recognition that human development occurs across levels simultaneously from molecular changes to broader cultural systems. Yet it remains challenging to integrate across levels and scholarly disciplines.
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