The type of palliative procedures (PP) for complex univentricular circulation (UC) changed significantly during the 80ies. Between 07/86 and 02/91 77 patients (pts) presented with UC to eventually undergo a modified Fontan-Kreutzer-type-operation (MFKTO). 33 pts had been previously palliated, 22 of whom were accepted for MFKTO as well as an additional 9 not palliated pts (group A: 31 pts; 20 PP). 11 previously palliated pts and 35 new pts required new palliations (group B: 46 pts; 89 PP), 34 of which resulted in 13 MFKTO. Prerequisites to be met for MFKTO are: undistorted PA-anatomy; absence of subaortic stenosis (SAS); Qp greater than 2.5 l/min/m2; PAP less than 20 mm Hg; Rp less than 3 Wood Units. All earlier PP in group A (31 BTS, 3 PAB, 2 PA-valvotomy/dil.) merely prolonged survival by only adjusting Qp. In group B PP comprise reconstruction of pulmonary arteries, aortic arch and isthmus as well as bypass or resection of SAS or atrial septectomy. Mortality for complex PP (group B) was 32.5% (15/46). 9 of these pts were neonates, 7 after modified Norwood procedures. In an attempt to plan a MFKTO for all pts presenting with UC (group B), complex PP was necessary. The high mortality is due to lesions in pts who would not have survived if only closed PP were applied.
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J Orthop Surg Res
January 2025
Department of Orthopedics and Traumatology, Faculty of Medicine, Ege University, Bornova, 35100, Izmir, Turkey.
Purpose: To evaluate the radiological and clinical outcomes in two patient groups: first, varus aligned medial meniscus posterior root tear (MMPRT) patients who underwent posteromedial open wedge high tibial osteotomy (PMOWHTO) and simultaneous root repair; second, patients with varus medial knee osteoarthritis without MMPRT who underwent PMOWHTO.
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Departmento of Pathology, Evandro Chagas Institute, Ministry of Health, Ananindeua 67030-000, PA, Brazil.
Necroptosis is a regulated form of cell death implicated in several pathological conditions, including viral infections. In this study, we investigated the expression and correlation of necroptosis markers MLKL, RIP1 and RIP3 in human liver tissue from fatal cases of yellow fever (YF) using immunohistochemistry (IHC). The liver samples were obtained from 21 YF-positive individuals and five flavivirus-negative controls with preserved liver parenchymal architecture.
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Department of Physical Therapy, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa 3498838, Israel.
Background/objectives: Malnutrition and sarcopenia are interrelated health concerns among the elderly. Each condition is associated with increased mortality, morbidity, rehospitalization rates, longer hospital stays, higher healthcare costs, and reduced quality of life. Their combination leads to the development of "Malnutrition-Sarcopenia Syndrome" (MSS), characterized by reductions in body weight, muscle mass, strength, and physical function.
View Article and Find Full Text PDFPharmaceuticals (Basel)
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Canakinumab, a humanized anti-IL-1β monoclonal antibody, is known for its ability to suppress IL-1β-mediated inflammation. However, continuous monitoring of its safety remains essential. Thus, we comprehensively evaluated the safety signals of canakinumab by data mining from FAERS.
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Exercise and Rehabilitation Sciences Institute, Postgraduate, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile.
To determine whether 448 kHz capacitive-resistive monopolar radiofrequency (CRMR) after platelet-rich-plasma (PRP) injections can further reduce pain sensation within the first 72 h in an active population with patellar chondropathy. One-hundred fifty-three active patients with patellar chondropathy grade II-III were followed for three days after PRP injections with and without CRMR under a control-placebo study. They were clinically evaluated for pain sensation using a visual analog scale ranging from zero (no pain sensation) to ten (highest pain sensation).
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