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Umbrella review of economic evaluations of interventions for the prevention and management of healthcare-associated infections in adult hospital patients.
J Hosp Infect
January 2025
HCAI/AMR Modelling and Evaluations Team, UK Health Security Agency, London, UK.
Introduction: Healthcare-associated infections result in worse outcomes for patients and greater financial burden. An estimated 4.8 million HCAIs occurred in hospitals across Europe in 2022-23.
View Article and Find Full Text PDFOptimizing the production and efficacy of antimicrobial bioactive compounds from in combating multi-drug-resistant pathogens.
Front Cell Infect Microbiol
January 2025
Mkelly Biotech Pvt Ltd., Mohali, Punjab, India.
Background: The rise of antibiotic-resistant pathogens has intensified the search for novel antimicrobial agents. This study aimed to isolate from local soil samples and evaluate its antimicrobial properties, along with optimizing the production of bioactive compounds.
Methods: Soil samples were collected from local regions, processed, and analysed for Streptomyces strains isolation using morphological characteristics and molecular identification through 16S rRNA gene PCR assay.
Nanobubble Ozone Stored in Hyaluronic Acid-Decorated Liposome Solutions: Inactivating Antibiotic-Resistant Bacteria and Genotoxicity, Sub-Acute and Sub-Chronic Toxicity Tests.
Infect Drug Resist
January 2025
Department of Medical Biochemistry, Faculty of Medicine, Bandırma Onyedi Eylül University, Bandırma/Balıkesir, Turkey.
Introduction: Nanobubble ozone stored in hyaluronic acid-decorated liposomes (patent application PCT/TR2022/050177) was used, and the Minimum Inhibitory Concentration (MIC) was found to be 1562 ppm. (patient isolate), (patient isolate), (MRSA) (ATCC12493), and (ATCC25922) bacteria, which are hospital-acquired and healthcare-associated infections, were used. A time-dependent efficacy study was conducted at 1600 ppm.
View Article and Find Full Text PDFPotent human antibodies against SpA5 identified by high-throughput single-cell sequencing of phase I clinical volunteers' B cells.
iScience
January 2025
Institute of Respiratory Diseases, Xinqiao Hospital, Third Military Medical University (Army Medical University), Chongqing 400037, China.
The drug resistance problem of needs to be solved urgently. Here, we report the rapid identification of human antibodies by high-throughput single-cell RNA and VDJ sequencing of memory B cells derived from 64 volunteers immunized with recombinant five-component vaccine (clinical phase I). From 676 antigen-binding IgG1 clonotypes, TOP10 sequences were selected for expression and characterization, with the most potent one, Abs-9, having nanomolar affinity for the pentameric form of the specific antigen protein A.
View Article and Find Full Text PDFGender-specific antibiotic-resistance patterns and characterization of bacterial flora of undergraduate students' mobile phones and associated factors at a Nigerian university.
BMC Microbiol
January 2025
Department of Biology, Microbiology and Science Laboratory Technology, Faculty of Sciences, Nile University of Nigeria, FCT, Abuja, 900001, Nigeria.
Background: Technological development has led to the wide use of mobile phones. However, the role of the hand-held device in the possible spread of antibiotic-resistant bacterial pathogens considering gender variation, especially among Nigerian undergraduates is poorly understood. This study aimed to assess bacterial isolates recovered from male and female mobile phones for antibiotic resistance and determine possible factors that could facilitate their spread.
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