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Development of a Sensitive Enzyme Immunoassay Using Phage-Displayed Antigen-Binding Fragments for Zearalenone Detection in Cereal Samples.
Foods
February 2025
School of Food Science and Engineering, Hainan University, Haikou 570228, China.
Zearalenone (ZEN), a non-steroidal estrogenic mycotoxin, contaminates animal feed and grain crops, thereby entering the food chain and posing a significant threat to human health. Consequently, there is an urgent need for a sensitive and rapid method for detecting trace levels of ZEN. In this study, we developed a phage-displayed antigen-binding fragment (Fab-phage) and established a Fab-phage-based enzyme-linked immunosorbent assay (Fab-pELISA) for ZEN detection.
View Article and Find Full Text PDFAn expanded framework for Swab Touch Spray-Mass Spectrometry towards the detection of allergenic protein residues on food preparation surfaces.
Anal Chim Acta
May 2025
Department of Chemical Engineering and Analytical Chemistry, University of Barcelona, Av. Diagonal 645, Barcelona, E-08028, Spain.
Background: Ambient Mass Spectrometry (AMS) encompasses a group of techniques that have emerged as powerful strategies for direct, in-situ and high-throughput analysis, also in compliance with the principles of green analytical chemistry. Swab Touch Spray-Mass Spectrometry (Swab TS-MS) is a home-made AMS technique that involves the use of a medical swab as sampling tool and electrospray probe. To date, Swab TS-MS has been applied only for the analysis of small molecules, especially in forensic and medical fields, leaving the analysis of peptides and proteins still unexplored.
View Article and Find Full Text PDFMicrofluidic isolation and release of live disseminated breast tumor cells in bone marrow.
PLoS One
March 2025
Department of Mechanical and Aerospace Engineering, Interdisciplinary Microsystems Group, Gainesville, Florida, United States of America.
Breast cancer represents a significant therapeutic challenge due to its aggressive nature and resistance to treatment. A major cause of treatment failure in breast cancer is the presence of rare, low-proliferative disseminated tumor cells (DTCs) in distant organs including the bone marrow. This study introduced a microfluidic-based approach to improve the immunodetection and isolation of these rare DTCs for downstream analysis, with an emphasis on optimizing immunocapture, release, and enrichment methods of live DTCs as compared to the standard approach for blood-borne circulating tumor cells (CTCs).
View Article and Find Full Text PDFA cost-effectiveness study of PSMA-PET/CT for the detection of clinically significant prostate cancer.
Eur J Nucl Med Mol Imaging
March 2025
Department of Medical Imaging, Radboud University Medical Center, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Background: Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is currently under evaluation for detecting clinically significant prostate cancer. The PSMA-PET/CT may complement the current standard diagnostic pathway for prostate cancer, which includes prostate-specific antigen (PSA) testing and multiparametric magnetic resonance imaging (mpMRI). This study evaluated the cost-effectiveness and quality of life impact of incorporating PSMA-PET/CT into this diagnostic algorithm.
View Article and Find Full Text PDFAdvances in carcinoembryonic antigen detection: a review of clinical applications and standardization.
Anal Bioanal Chem
March 2025
Division of Chemical Metrology and Analytical Science, National Institute of Metrology (Key Laboratory of Chemical Metrology and Applications On Nutrition and Health for State Market Regulation), Beijing, 100029, China.
Carcinoembryonic antigen (CEA) is among the earliest identified tumor markers and remains extensively utilized in the diagnosis and management of colorectal cancer. The detection of CEA presents considerable challenges in the field of analytical chemistry, given its complexity. The most prevalent detection approach is the immunoassay, including the chemiluminescence immunoassay commonly employed in clinical settings; however, discrepancies between various methods persist.
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