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Environ Sci Technol Lett
October 2024
Soller Environmental, Berkeley, California 94703, United States.
Increasing pressures on traditional sources of water have accelerated the adoption of water reuse throughout the world. A key consideration for communities pursuing water reuse is understanding the amount of treatment that is needed to ensure adequate human health protection. Several U.
View Article and Find Full Text PDFAIDS Behav
January 2025
Department of Human Development and Family Sciences, University of Connecticut, Storrs, CT, USA.
Healthy aging is an important area of research across many populations, but less work has focused on this area among sexual and gender diverse individuals relative to the general population. On the whole, it is known that as the U.S.
View Article and Find Full Text PDFBrain Sci
January 2025
Biomedical Research Center, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224, USA.
The molecular biology of Huntington's Disease (HD) has grown substantially, with pathological considerations extending to genetic modifiers, epigenetic changes, transcriptomics, the proteome, and the metabolome. The metabolome and proteome are especially intriguing in that they most directly reflect the functional state of the cellular environment, which may involve some combination of pathology as well as compensation. We assessed CSF proteomics from eight participants by their functional severity (TFC range 3-13), with 47 proteins having a minimum r-value of 0.
View Article and Find Full Text PDFbioRxiv
January 2025
Center for Research on Genomics and Global Health, National Human Genome Research Institute, Bethesda, Maryland, USA.
The Research Program () seeks to accelerate biomedical research and address the underrepresentation of minorities by recruiting over one million ethnically diverse participants across the United States. A key question is how self-identification with discrete, predefined race and ethnicity categories compares to genetic diversity at continental and subcontinental levels. To contextualize the genetic diversity in , we analyzed ~2 million common variants from 230,016 unrelated whole genomes using classical population genetics methods, alongside reference panels such as the 1000 Genomes Project, Human Genome Diversity Project, and Simons Genome Diversity Project.
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