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Procalcitonin for Early Detection of Pharyngocutaneous Fistula after Total Laryngectomy: A Pilot Study.
Cancers (Basel)
February 2024
Unit of Otorhinolaryngology, Department of Mental and Physical Health and Preventive Medicine, University Luigi Vanvitelli, 80131 Naples, Italy.
Article Synopsis
- The study aimed to determine if procalcitonin (PCT) can be an early indicator of pharyngocutaneous fistulas (PCF) in head and neck cancer patients who had total laryngectomy.
- Conducted between January 2019 and March 2022, the study monitored blood chemistry, including PCT levels, at several key intervals: before surgery and on days 5 and 20 post-operation, plus when PCF symptoms appeared.
- The results indicated that PCT levels significantly differed between patients with and without PCF, suggesting it could be a valuable tool for early detection of this complication and aiding in appropriate antibiotic treatment.
A genetic and virulence characterization of Brazilian strains of .
Front Microbiol
November 2023
Institute of Biological and Health Sciences, Federal University of Alagoas, Maceió, Brazil.
() is considered the primary causative agent of porcine enzootic pneumonia (EP), a chronic contagious respiratory disease that causes economic losses. Obtaining new pathogenic isolates and studying the genome and virulence factors are necessary. This study performed a complete sequencing analysis of two Brazilian strains, UFV01 and UFV02, aiming to characterize the isolates in terms of the virulence factors and sequence type.
View Article and Find Full Text PDFSinonasal microbiome and inflammatory profiles in fungal ball and chronic rhinosinusitis.
Auris Nasus Larynx
April 2024
Department of Otolaryngology-Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
Objective: Fungal balls (FB) are the main form of non-invasive fungal rhinosinusitis found in immunocompetent hosts. Bacterial coinfection affects clinical symptoms. We investigated the sinonasal microbiome and inflammatory profiles in FB and chronic rhinosinusitis (CRS) patients.
View Article and Find Full Text PDFMucosal Microbiome Disruption in Acute Laryngeal Injury Following Intubation.
Otolaryngol Head Neck Surg
March 2024
Department of Otolaryngology-HNS, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
The objective of this study was to characterize mucosal microbial shifts in patients with acute laryngeal injury (ALgI) after intubation. This cross-sectional study included 20 patients with ALgI who underwent early endoscopic intervention with tissue culture, 20 patients with idiopathic subglottic stenosis (iSGS) who underwent tissue culture during the routine endoscopic intervention, and 3 control patients who underwent mucosal swab culture. 70% of the ALgI patients had a positive culture compared to 5% of the iSGS patients and none of the controls.
View Article and Find Full Text PDFMicrobiota dysbiosis in hereditary angioedema patients.
World Allergy Organ J
August 2023
Division of Allergy and Immunology, Department of Pediatrics, Research and Training Hospital of Sakarya University Medical Faculty, Adapazarı, Sakarya, Türkiye.
I have read the article titled "" by Wang et al (2022) with great interest. This study examined the change in throat microbiota and its association with laryngeal edema (LE) attacks and attack severity in hereditary angioedema (HAE) patients. This study demonstrated the comparative richness of Bacteroidetes and Prevotellaceae in recent LE attacks and detected positive association between the attack severity scores and Bacteroidetes richness.
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