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Lactate-induced protein lactylation in cancer: functions, biomarkers and immunotherapy strategies.
Front Immunol
January 2025
Department of Medical Laboratory, Affiliated Hospital of Jiujiang University, Jiujiang, Jiangxi, China.
Lactate, long viewed as a byproduct of glycolysis and metabolic waste. Initially identified within the context of yogurt fermentation, lactate's role extends beyond culinary applications to its significance in biochemical processes. Contemporary research reveals that lactate functions not merely as the terminal product of glycolysis but also as a nexus for initiating physiological and pathological responses within the body.
View Article and Find Full Text PDFEffectiveness of an External Cooling and Vibrating Device vs Counterstimulation in Reducing Discomfort of Inferior Alveolar Nerve Block in Pediatric Dental Patients: A Single-blinded Randomized Controlled Trial.
Int J Clin Pediatr Dent
December 2024
Department of Pedodontics, Government Dental College, Alappuzha, Kerala, India.
Background: Pain management in pediatric patients during dental procedures is very important. Here, the traditional method of behavior management is compared with novel methods.
Aim: To compare and determine the effectiveness of an external cooling and vibrating device vs counterstimulation with the conventional technique in reducing the fear and discomfort of pediatric dental patients aged 5-7 years during inferior alveolar nerve block (IANB).
Nudging in the nursing home: A qualitative interpretive study.
Int J Nurs Stud Adv
June 2025
Faculty of Health Sciences, Department of Nursing and Health Promotion, OsloMet-Oslo Metropolitan University, Oslo, Norway.
Background: Nudging involves deliberately changing the environment or context to induce better choices. Several studies consider such methods unethical manipulation that threatens the principles of informed consent and autonomy, which are particularly vital in healthcare. Others argue that nudging respects personal freedom because it is not in conflict with the person's explicit values or choices, beneficial, and easy to resist.
View Article and Find Full Text PDF3D printing of biological tooth with multiple ordered hierarchical structures.
Mater Today Bio
February 2025
State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, College of Materials Science and Engineering, Donghua University, Shanghai, 201620, PR China.
Natural teeth fulfill functional demands by their heterogeneity. The composition and hydroxyapatite (HAp) nanostructured orientation of enamel differ from those of dentin. However, mimicking analogous materials still exhibit a significant challenge.
View Article and Find Full Text PDFStem cell-derived exosome delivery systems for treating atherosclerosis: The new frontier of stem cell therapy.
Mater Today Bio
February 2025
Institute of Optical Functional Materials for Biomedical Imaging, School of Chemistry and Pharmaceutical Engineering, Shandong First Medical University & Shandong Academy of Medical Science, Taian, Shandong, 271016, PR China.
Cardiovascular diseases (CVDs) are a leading cause of mortality worldwide. As a chronic inflammatory disease with a complicated pathophysiology marked by abnormal lipid metabolism and arterial plaque formation, atherosclerosis is a major contributor to CVDs and can induce abrupt cardiac events. The discovery of exosomes' role in intercellular communication has sparked a great deal of interest in them recently.
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