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Tacrolimus and diabetic rodent models.
Pharmacol Rep
January 2025
Department of Pharmacy, The First People's Hospital of Changzhou/The Third Affiliated Hospital of Soochow University, Changzhou, 213003, Jiangsu, China.
Tacrolimus (TAC) is an immunosuppressant widely utilized in organ transplantation. One of its primary adverse effects is glucose metabolism disorder, which significantly increases the risk of diabetes. Investigating the molecular mechanisms underlying TAC-induced diabetes is essential for developing effective prevention and treatment strategies for these adverse effects.
View Article and Find Full Text PDFThe value of early root development traits in breeding programs for biomass yield in perennial ryegrass (Lolium perenne L.).
Theor Appl Genet
January 2025
Center for Quantitative Genetics and Genomics, Aarhus University, Slagelse, Denmark.
Early root traits, particularly total root length, are heritable and show positive genetic correlations with biomass yield in perennial ryegrass; incorporating them into breeding programs can enhance genetic gain. Perennial ryegrass (Lolium perenne L.) is an important forage grass widely used in pastures and lawns, valued for its high nutritive value and environmental benefits.
View Article and Find Full Text PDFAssessing water quality restoration measures in Lake Pampulha (Brazil) through remote sensing imagery.
Environ Sci Pollut Res Int
January 2025
LEESU, Ecole des Ponts Paris Tech, UPEC, AgroParisTech, F-77455 Marne-la-Vallée, Paris, France.
Urban reservoirs are frequently exposed to impacts from high population density, polluting activities, and the absence of environmental control measures and monitoring. In this study, we investigated the use of satellite imagery to assess restoration measures and support decision-making in a hypereutrophic urban reservoir. Since 2016, Lake Pampulha (Brazil) has undergone restoration measures, including the application of Phoslock®, to mitigate its poor water quality conditions.
View Article and Find Full Text PDFImpact of Multimodal Prompt Elements on Diagnostic Performance of GPT-4V in Challenging Brain MRI Cases.
Radiology
January 2025
From the Institute of Diagnostic and Interventional Neuroradiology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Ismaninger Strasse 22, Munich 81675, Germany.
Background Studies have explored the application of multimodal large language models (LLMs) in radiologic differential diagnosis. Yet, how different multimodal input combinations affect diagnostic performance is not well understood. Purpose To evaluate the impact of varying multimodal input elements on the accuracy of OpenAI's GPT-4 with vision (GPT-4V)-based brain MRI differential diagnosis.
View Article and Find Full Text PDFFalling racial inequality and rising educational inequality in US prison admissions for drug, violent, and property crimes.
Proc Natl Acad Sci U S A
January 2025
Department of Sociology and Criminology, Butler University, Indianapolis, IN 46208.
Using administrative and survey data, we show that there has been a sea change in the contours of American imprisonment. At the end of the twentieth century, inequality in the prison admission rates of Black and White Americans was comparable to inequality in the prison admission rates of people with and without a college education. However, educational inequality is now much greater than racial inequality in prison admissions for all major crime types.
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