A 56-year-old man presented with a 30-year history of a slowly enlarging lesion on the sole of his right foot. A biopsy showed an anastomosing network of small cuboidal cells with the formation of occasional sweat ductal lumina and a marked fibrovascular stroma. The histological findings were interpreted as consistent with the diagnosis of an eccrine syringofibroadenoma. Using immunohistochemistry all the tumour cells were positively stained by the pan-cytokeratin antibody Lu-5 and an antibody to the cytokeratins 1/5/10/11. In addition the luminal ductal cells expressed cytokeratin 19 and CEA. Tumour cells were negative for cytokeratins 1, 7, 8, 13 and 18 and did not express vimentin and GCDFP-15. The results indicate that the eccrine syringofibroadenoma is differentiated towards the dermal eccrine duct.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1111/j.1365-2133.1992.tb00655.x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
An 8-year retrospective analysis of 19 cases of eccrine poroma in Hainan, China.
Arch Dermatol Res
January 2025
Department of Plastic and Dermatological Surgery, Affliated Dermatology Hospital of Hainan Medical University, The Fifth People's Hospital of Hainan Province, Haikou, China.
A Rare Case of Pigmented Eccrine Poroma on the Trunk Mimicking Malignant Melanoma.
Clin Case Rep
December 2024
Department of Dermatology Razi Hospital, Tehran University of Medical Sciences (TUMS) Tehran Iran.
Representative clinical images in this study can increase awareness regarding the clinical similarity between this benign adnexal tumor and malignant melanoma and highlight the importance of pathological examination.
View Article and Find Full Text PDFEccrine poroma versus eccrine porocarcinoma: a comparative study of clinicopathological features.
An Bras Dermatol
December 2024
Department of Dermatology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address:
Background: Eccrine porocarcinoma (EPC) is a rare cutaneous neoplasm, commonly arising from its benign counterpart, eccrine poroma (EP), but potential unrevealed clinicopathological differences between them are not well understood.
Objectives: This study aimed to identify clinicopathological features of EP and EPC and describe the factors that may be associated with the malignant transformation of EP by comparing the two groups.
Methods: A total of 37 cases of EP and 22 cases of EPC diagnosed between January 2017 and June 2023 were retrospectively reviewed, and the clinical and histopathological characteristics were compared using statistical methods.
A Pedunculated Eccrine Poroma Presented as a Skin Tag on the Right Thigh of a Female Individual: A Case Report.
Cureus
October 2024
Department of Medicine, Broomfield Hospital, Mid and South Essex National Health Service (NHS) Foundation Trust, Essex, GBR.
Poroma is a relatively rare benign adnexal neoplastic lesion that usually affects elderly patients in the extremities, with an unclear pathogenesis. It is notable for having a variety of morphological appearances that make diagnosis challenging, particularly when observed on an uncommon anatomical site. Here, we present a case of a woman in her mid-50s who presented with a skin pedunculated lesion over the right thigh.
View Article and Find Full Text PDFUndifferentiated Pleomorphic Sarcoma with Reactive Eccrine Syringofibroadenoma: A Case Report.
Dermatopathology (Basel)
October 2024
Southern Regional Hospital of Tropical Dermatology-Trang Province, Department of Medical Services, Ministry of Public Health, Trang 92000, Thailand.
Article Synopsis
- Undifferentiated pleomorphic sarcoma (UPS) is a highly aggressive soft tissue cancer with a poor prognosis, often diagnosed only after metastasis has occurred.
- Eccrine syringofibroadenoma (ESFA) is a rare skin lesion linked to eccrine ducts, with one subtype arising as a reaction to other inflammatory or neoplastic conditions.
- A case study is presented involving a 70-year-old man who had both UPS and reactive ESFA, highlighted by a specific skin lesion on his palm characterized by atypical cells and distinctive epidermal changes.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!