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Context: Early diagnosis of coronavirus disease 2019 (COVID-19) and patient isolation are important for both individual patient care and disease containment. The diagnosis is confirmed by testing for the presence of nasopharyngeal viral RNA with a polymerase chain reaction assay, which has limited availability, variable turnaround time, and a high false-negative rate. The authors report that a rapid laboratory test, the eosinophil count, readily obtained from a routine complete blood cell count (CBC), may provide actionable clinical information to aid in the early recognition of COVID-19 in patients, as well as provide prognostic information.
View Article and Find Full Text PDFBiphasic effect-time courses in man after formoterol inhalation: eosinopenic and hypokalemic effects and inhibition of allergic skin reactions.
J Pharmacol Exp Ther
November 1997
Department of Clinical Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands.
The kinetics of inhaled racemic formoterol and its effects on the size of the early cutaneous reaction to intradermal injection of an allergen, eosinopenia and hypokalemia were assessed by pharmacokinetic-pharmacodynamic modeling. After inhalation of either 120 microg of formoterol or placebo, blood samples were taken and skin tests were performed in seven healthy subjects. A two-compartment model was needed to describe the observed formoterol plasma concentration-time curves.
View Article and Find Full Text PDFHypereosinophilia in association with pulmonary tuberculosis in a rural population in south India.
Indian J Med Res
November 1994
Department of Chest Diseases, Christian Medical College, Vellore.
In a prospective study conducted in four villages of North Arcot Ambedkar district of Tamil Nadu in south India over a 5 yr period from 1981-86, 279 patients were detected to have pulmonary tuberculosis (PTB). Thirty one of them were found to have associated hypereosinophilia (HE) with total blood eosinophil level of > or = 2000 per cumm; besides cough with expectoration they also complained of dyspnoea and wheeze. Twelve of the 18 patients with intestinal parasites had remission with deworming agents alone.
View Article and Find Full Text PDFIt would be difficult for physicians or allergists to imagine doing without corticosteroids in managing difficult cases of bronchial asthma. It is beyond any doubt that CS act on many sites to help reverse the pathologic process of bronchial asthma. Corticosteroids enhance the beta-adrenergic response to relieve the muscle spasm.
View Article and Find Full Text PDF[Methods of assessing the toxic properties of polymeric filling materials (author's transl)].
Zahn Mund Kieferheilkd Zentralbl
January 1979
This paper discusses the results of experiments conducted with a view to determining the hidden effects of epoxy composites, which cannot generally be ascertained through the use of various toxicological, biochemical, immunological, allergic, morphological, and cytological methods of examination. To discover possible hidden effects of epoxy filling materials experimental use was made of the following methods: hunger diet, ethylalcohol supply, and composite extract supply. Shifts in functions of the organism were evaluated by the following criteria: weight dynamics of animals, histamine content of the blood, and eosinopenic reaction of the blood.
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