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Biomarkers.
Alzheimers Dement
December 2024
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA.
Background: Biorepositories play an integral role in the advancement of our understanding of neurodegenerative diseases and improving human health outcomes. Research efforts are accelerated when access to high-quality clinical specimens is made available from a large, diverse participant group. Indiana University is home to three important neurodegenerative disease-focused biorepositories including the NIA-funded National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD), the NINDS-funded Biospecimen Exchange for Neurological Disorders (BioSEND), and the Michael J.
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Alzheimers Dement
December 2024
Icahn School of Medicine, Mount Sinai Hospital, New York, NY, USA.
Background: Adverse social exposome (indexed by national Area Deprivation Index [ADI] 80-100 or 'high ADI') is linked to structural inequities and increased risk of Alzheimer's disease neuropathology. Twenty percent of the US population resides within high ADI areas, predominantly in inner cities, tribal reservations and rural areas. The percentage of brain donors from high ADI areas within the Alzheimer's Disease Research Center (ADRC) brain bank system is unknown.
View Article and Find Full Text PDFBackground: Animal models provide a valuable basis for identification of conserved pathological substrates and processes underlying age-related diseases as well as neurobiological features supporting cognitive resilience in the aging brain. Behavioral measures are a fundamental component in the assessment of cognitive processes but are rarely standardized across laboratories. Currently, there is a scarcity of centralized and standardized data infrastructure for behavioral experiment data collected across laboratories which presents a barrier for data sharing, hypothesis generation, and collaboration.
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Alzheimers Dement
December 2024
Center for Health Disparities Research, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
Background: Working conditions and contexts may influence the development of Alzheimer's Disease and related dementias (ADRD), exposing individuals to modifiable risk factors across their life. Measurement of ADRD pathology at autopsy provides a gold standard outcome for evaluating the effects of lifetime exposures, but approaches to quantify ante-mortem work exposures are limited. Here we describe a new method to retrospectively capture occupational histories by systematically extracting occupational information using archival public records- i.
View Article and Find Full Text PDFBiomarkers.
Alzheimers Dement
December 2024
National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA.
Background: While Aβ and tau pathologies are central to AD, emerging evidence suggests the coexistence of Lewy body pathology (α-synuclein aggregates), further contributing to neurodegenerative processes. Our objective was to investigate the association between CSF α-synuclein seed amplification assay (SAA) positivity and in vivo neuroimaging metrics of florbetapir-PET and flortaucipir-PET retention, as well as atrophy measured by structural-MRI, with a focus on Aβ+ cognitively impaired (MCI and Dementia due to AD) individuals.
Method: Participants from ADNI who were Aβ+ (CSF Aβ42<980 pg/mL) and had undergone SAA analysis, along with based on florbetapir-PET, flortaucipir-PET, or structural-MRI scans within one year of CSF sample collection, were included in the analysis (Table 1).
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