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Relationship between the complement system and serum lipid profile in patients with rheumatoid arthritis.
Front Immunol
July 2024
Division of Rheumatology , Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain.
Background: The complement system has been linked to the etiopathogenesis of rheumatoid arthritis (RA). Patients with RA exhibit a dysregulated profile of lipid molecules, which has been attributed to the inflammation present in the disease. In this study, we aimed to evaluate the association between a comprehensive assessment of the complement system and the lipid profile of patients with RA.
View Article and Find Full Text PDFInfiltrating myeloid cell-derived properdin markedly promotes microglia-mediated neuroinflammation after ischemic stroke.
J Neuroinflammation
November 2023
Department of Neurology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, 321 Zhongshan Road, Nanjing, Jiangsu, 210008, People's Republic of China.
Background: Emerging evidence has shown that myeloid cells that infiltrate into the peri-infarct region may influence the progression of ischemic stroke by interacting with microglia. Properdin, which is typically secreted by immune cells such as neutrophils, monocytes, and T cells, has been found to possess damage-associated molecular patterns (DAMPs) properties and can perform functions unrelated to the complement pathway. However, the role of properdin in modulating microglia-mediated post-stroke neuroinflammation remains unclear.
View Article and Find Full Text PDFHBSP improves kidney ischemia-reperfusion injury and promotes repair in properdin deficient mice enhancing phagocytosis of tubular epithelial cells.
Front Immunol
May 2023
Department of Cardiovascular Sciences, College of Life Sciences, University of Leicester, University Hospitals of Leicester NHS Trust, Leicester, United Kingdom.
Phagocytosis plays vital roles in injury and repair, while its regulation by properdin and innate repair receptor, a heterodimer receptor of erythropoietin receptor (EPOR)/β common receptor (βcR), in renal ischaemia-reperfusion (IR) remains unclear. Properdin, a pattern recognition molecule, facilitates phagocytosis by opsonizing damaged cells. Our previous study showed that the phagocytic function of tubular epithelial cells isolated from properdin knockout () mouse kidneys was compromised, with upregulated EPOR in IR kidneys that was further raised by at repair phase.
View Article and Find Full Text PDFInitial properdin binding contributes to alternative pathway activation at the surface of viable and necrotic cells.
Eur J Immunol
April 2022
Division of Nephrology and Transplant Medicine, Department of Medicine, Leiden University Medical Center, Leiden, The Netherlands.
Properdin, the only known positive regulator of the complement system, stabilizes the C3 convertase, thereby increasing its half-life. In contrast to most other complement factors, properdin is mainly produced extrahepatically by myeloid cells. Recent data suggest a role for properdin as a pattern recognition molecule.
View Article and Find Full Text PDFHuman Properdin Released By Infiltrating Neutrophils Can Modulate Influenza A Virus Infection.
Front Immunol
February 2022
Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge, United Kingdom.
Article Synopsis
- * The study focused on properdin's role against Influenza A virus (IAV), demonstrating that it interacts with certain viral proteins and influences immune responses in a subtype-specific manner.
- * Properdin was shown to suppress H1N1 replication while promoting H3N2 replication, triggering different inflammatory responses in infected cells, thus highlighting its dual role during viral infections.
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