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Crystalline H-aggregate nanoparticles for detecting dopamine release from M17 human neuroblastoma cells.
J Mater Chem B
October 2022
Department of Materials Science and Engineering and Advanced Materials Processing and Analysis Center, Orlando, Florida 32816, USA.
Dopamine (DA) is an important neurotransmitter, which is essential for transmitting signals in neuronal communications. The deficiency of DA release from neurons is implicated in neurological disorders. There has been great interest in developing new optical probes for monitoring the release behavior of DA from neurons.
View Article and Find Full Text PDFIdentification of Agents Active against Methicillin-Resistant Staphylococcus aureus USA300 from a Clinical Compound Library.
Pathogens
September 2017
Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.
Methicillin-resistant (MRSA) poses a significant threat for effective treatment of several difficult-to-treat infections in humans. To identify potential new treatment options for MRSA infections, we screened a clinical compound library consisting of 1524 compounds using a growth inhibition assay in 96-well plates. We identified 34 agents which are either bacteriostatic or bactericidal against log-phase clinical MRSA strain USA300.
View Article and Find Full Text PDFMolecular Recognition and Visual Detection of G-Quadruplexes by a Dicarbocyanine Dye.
Chemistry
September 2015
Institute of Biochemistry, Ernst-Moritz-Arndt University Greifswald, Felix-Hausdorff-Str. 4, 17487 Greifswald (Germany).
The interactions of a dicarbocyanine dye 3,3'-diethylthiadicarbocyanine, DiSC2(5), with DNA G-quadruplexes were studied by means of a combination of various spectroscopic techniques. Aggregation of excess dye as a result of its positive charge is promoted by the presence of the polyanionic quadruplex structure. Specific high-affinity binding to the parallel quadruplex of the MYC promoter sequence involves stacking of DiSC2(5) on the external G-tetrads; the 5'-terminal tetrad is the favored binding site.
View Article and Find Full Text PDFHighly penetrative, drug-loaded nanocarriers improve treatment of glioblastoma.
Proc Natl Acad Sci U S A
July 2013
Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
Current therapy for glioblastoma multiforme is insufficient, with nearly universal recurrence. Available drug therapies are unsuccessful because they fail to penetrate through the region of the brain containing tumor cells and they fail to kill the cells most responsible for tumor development and therapy resistance, brain cancer stem cells (BCSCs). To address these challenges, we combined two major advances in technology: (i) brain-penetrating polymeric nanoparticles that can be loaded with drugs and are optimized for intracranial convection-enhanced delivery and (ii) repurposed compounds, previously used in Food and Drug Administration-approved products, which were identified through library screening to target BCSCs.
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