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Highly sensitive and selective detection of SARS-CoV-2 spike protein S1 using optically-active nanocomposite-coated melt-blown masks.
Anal Chim Acta
January 2025
Department of Biomaterials, Saveetha Dental College and Hospitals, SIMATS, Saveetha University, Chennai, 600077, India. Electronic address:
Detection of viruses, including coronavirus (SARS-CoV-2), via facile, fast, and optical methods is highly important to control pandemics. In this regard, optically-active nanomaterials and nanoparticles (NPs) are a wise choice due to their long-term stability, ease of functionalization, and modifications. In this work, a nanocomposite based on NiFe layered double hydroxide (LDH) and ZIF-67 metal-organic framework (MOF) was designed and synthesized, and decorated on the surface of the melt-blown mask.
View Article and Find Full Text PDFClinical Decision Support and Cardiometabolic Medication Adherence: A Randomized Clinical Trial.
JAMA Netw Open
January 2025
HealthPartners Institute, Bloomington, Minnesota.
Importance: Medication adherence is important for managing blood pressure (BP), low-density lipoprotein cholesterol (LDL-C), and hemoglobin A1c (HbA1c). Interventions to improve medication adherence are needed.
Objective: To examine the effectiveness of an intervention using algorithmic identification of low medication adherence, clinical decision support to physicians, and pharmacist outreach to patients to improve cardiometabolic medication adherence and BP, LDL-C, and HbA1c control.
Biomarkers.
Alzheimers Dement
December 2024
UNAM, School of Medicine, Department of Physiology, CDMX, DF, Mexico.
Background: Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia and insulin resistance. Historically, it is linked to greater cognitive decline and risk of Alzheimer's dementia. Although deregulations in the insulin signaling pathway have been identified, further investigation is needed.
View Article and Find Full Text PDFPublic Health.
Alzheimers Dement
December 2024
Kaiser Permanente Northern California Division of Research, Oakland, CA, USA.
Background: Though high HbA (marker for glycemic control) is associated with increased dementia risk, the influence of longitudinal changes in HbA is unclear. We examined the association between 10-year trajectories of HbA and dementia risk in a large, diverse sample of people in Northern California.
Method: In a cohort of 32, 914 patients with Type 2 diabetes aged ≥ 50 years, we obtained repeated measures of HbA, dementia diagnoses, and comorbidities from electronic medical records (EMR) from 1996-20021.
Biomarkers.
Alzheimers Dement
December 2024
Institute of Biomedical Engineering, Shenzhen Bay Laboratory, Shenzhen, Guangdong, China.
Background: Plasma biomarkers of Alzheimer's disease (AD)-related pathological changes are considered as proxies of their changes in the brain. Recent cohort studies reported very early changes in plasma astrocytic marker glial fibrillary acidic protein (GFAP) in the AD spectrum, which is relative to the onset of neuropathology. Little is known about the association between plasma soluble triggering receptor expressed on myeloid cells 2 (sTREM2) and primary AD pathology.
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