Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Mass Balance Recovery, Absorption, Metabolism, and Excretion of Elinzanetant in Healthy Human Volunteers and in vitro Biotransformation.
Eur J Drug Metab Pharmacokinet
December 2024
Preclinical Development-Drug Metabolism and Pharmacokinetics, Bayer AG, Berlin, Germany.
Background: Elinzanetant is a dual neurokinin-1,3 receptor antagonist in development for the treatment of menopausal vasomotor symptoms. The objectives of these studies were to characterize the mass balance and biotransformation of elinzanetant.
Methods: In the clinical evaluation, whole blood, plasma, urine, and feces were collected from healthy fasted male volunteers (n = 6) following a single dose of 120 mg [C]-elinzanetant oral suspension for analysis of total radioactivity and metabolite profiling.
Essential role of sulfide oxidation in brain health and neurological disorders.
Pharmacol Ther
December 2024
Anesthesia Center for Critical Care Research, Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address:
Hydrogen sulfide (HS) is an environmental hazard well known for its neurotoxicity. In mammalian cells, HS is predominantly generated by transsulfuration pathway enzymes. In addition, HS produced by gut microbiome significantly contributes to the total sulfide burden in the body.
View Article and Find Full Text PDF[Preoperative protective preparation of the nasal mucosa of rhinological patients].
Vestn Otorinolaringol
November 2024
St. Luke Lugansk State Medical University, Lugansk, Russia.
Unlabelled: To reduce the inflammatory reaction that occurs in the nasal mucosa after surgical interventions, it seems promising to develop methods of preventive preparation of the epithelium to the effects of damaging factors in the preoperative period.
Objective: To evaluate the effectiveness of the protective effect of sodium deoxyribonuclease solution on the nasal mucosa in the preoperative period in rhinological patients.
Material And Methods: 71 patients were examined after septoplasty with vasotomy of the lower nasal concha for curvature of the nasal septum and vasomotor rhinitis.
Advancements in the Regulation of Different-Intensity Exercise Interventions on Arterial Endothelial Function.
Rev Cardiovasc Med
November 2023
School of Rehabilitation Medicine, Weifang Medical University, 261053 Weifang, Shandong, China.
Normal-functioning endothelium is crucial to maintaining vascular homeostasis and inhibiting the development and progression of cardiovascular diseases such as atherosclerosis. Exercise training has been proven effective in regulating arterial endothelial function, and the effect of this regulation is closely related to exercise intensity and the status of arterial endothelial function. With this review, we investigated the effects of the exercise of different intensity on the function of arterial endothelium and the underlying molecular biological mechanisms.
View Article and Find Full Text PDFEffects of magnesium supplementation on muscle soreness in different type of physical activities: a systematic review.
J Transl Med
July 2024
Department of Experimental and Clinical Medicine, University "Magna Græcia" of Catanzaro, Catanzaro, CZ, Italy.
Background: Magnesium is a micronutrient and an intracellular cation responsible for different biochemical reactions involved in energy production and storage, control of neuronal and vasomotor activity, cardiac excitability, and muscle contraction. Magnesium deficiency may result in impaired physical performance. Moreover, magnesium plays an important role on delayed onset muscle soreness after training.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!