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Development of HRP-assisted rGO-FET biosensors for high-precision measurement of serological steroid hormones.
Anal Chim Acta
January 2025
Department of Medical Biotechnology, College of Life Science and Biotechnology, Dongguk University, Seoul, 04620, Republic of Korea. Electronic address:
Background: Sarcopenia, which is associated with many pathways and molecular mechanisms, not only deteriorates the quality of life in old age but is also linked to various diseases. The ratio between cortisol and dehydroepiandrosterone sulfate (DHEAS) was utilized as a candidate method to diagnose sarcopenia. The hormones can fluctuate in concentration throughout the day, so monitoring the ratio between the two hormones is necessary.
View Article and Find Full Text PDFAssociations of gestational anxiety and depression with neonatal hair steroid levels.
Psychoneuroendocrinology
December 2024
R&D department, Division of Mental Health Services, Akershus University Hospital, Lørenskog, Norway; Department of Psychiatry, University of Helsinki, Helsinki, Finland; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
Objective: To investigate the association prenatal maternal depression and anxiety may have on the levels of neonatal hair steroids (i.e. cortisol, cortisone, and the cortisol/cortisone ratio) at birth.
View Article and Find Full Text PDFAn LC-MS/MS assay for simultaneous determination of 13 steroid hormones and two synthetic steroids in saliva: potential utility for paediatric population and beyond.
Scand J Clin Lab Invest
January 2025
Hormone Laboratory, Department of Medical Biochemistry and Biochemical Endocrinology and Metabolism Research Group, Oslo University Hospital, Aker, Oslo, Norway.
Saliva samples offer the possibility to obtain stress-free non-invasive samples, also for home-testing, especially useful when blood collection is either undesirable or difficult. The aim of this work was to develop an LC-MS/MS method to determine clinically relevant steroid hormones cortisol, cortisone, 11-deoxycortisol, 21-deoxycortisol, 17OH-progesterone, aldosterone, corticosterone, deoxycorticosterone, testosterone, androstenedione, DHEAS, DHEA, 17OH-pregnenolone, betamethasone and dexamethasone. A special effort was made to adapt the method to neonatal population with respect to choice of saliva as matrix, low sample volumes, selection of analytes and multiplexing.
View Article and Find Full Text PDFThe Effects of a Grape Seed Procyanidin Extract on Cytochrome P450 3A4 Activity and Inflammatory Mediators in the Lungs of Heavy Active and Former Smokers.
Int J Mol Sci
December 2024
Pulmonary, Critical Care and Sleep Section, New Mexico Veterans Administration Health Care System, University of New Mexico, Albuquerque, NM 87108, USA.
Grape seed procyanidin extract (GSE) is widely used to promote cardiovascular health and has purported anti-inflammatory properties. Chronic inflammation in the lungs caused by environmental toxins such as tobacco smoking plays a pivotal role in lung cancer development. In a modified phase I lung cancer chemoprevention study conducted in heavy active and former smokers using leucoselect phytosome (LP), a standardized grape seed procyanidin extract complexed with soy phospholipids to enhance bioavailability, three months of LP treatment favorably modulated a variety of surrogate endpoint biomarkers, including markers of cell proliferation.
View Article and Find Full Text PDFRegeneration of full thickness common extensor tendon tear after percutaneous microfragmented adipose graft.
Regen Med
October 2024
Regenerative Orthopedics and Sports Medicine, Rockville Pike #300, Rockville, MD 20852, USA.
Article Synopsis
- - Tennis elbow, also known as lateral epicondylitis, is a common injury among adults and is typically treated with rest, physical therapy, bracing, and anti-inflammatory drugs.
- - For severe cases with full thickness tears, surgery has been the main treatment, but a new case report discusses a 56-year-old man treated successfully with microfragmented adipose transfer after a corticosteroid injection caused a rupture.
- - Follow-up evaluations showed significant improvement, suggesting this treatment could be a viable alternative to surgery for full thickness tears, although more research is needed to confirm its effectiveness.
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